CAJ | 학술논문

目的探讨中国北方人群中腰围增加与糖尿病发病风险之间的关系.方法本研究采用前瞻性队列研究方法,以参加2006～2007年度开滦集团职工健康体检的101510名职工中空腹血糖(FPG)＜7.0mmol/L、无糖尿病病史、未使用降糖药物且FPG及腰围资料完整的89364名职工作为观察队列,排除2010～2011年度未参加体检者、FPG及腰周资料缺失者,最终纳入统计分析的有效数据为58426名.依据基线腰围测量值将观察对象分为肥胖组与非肥胖组,比较2组问糖尿病的发病率,同时依据基线腰围四分位数将观察对象分为4组,比较4组间糖尿病的发病率.用多因素logistic回归分析腰围增加与2型糖尿病发病风险的关系.结果 (1)肥胖组糖尿病发病率高于非肥胖组(8.02％对3.37％,P＜0.01).随着腰围的增加,糖尿病的发病率逐渐升高,第一分位、第二分位、第三分位和第四分位组的发病率分别为2.32％、3.62％、5.46％和8.89％.按性别分层后,男性4组糖尿病的发病率分别为2.84％、3.65％、5.32％和8.95％,女性分别为1.50％、3.41％、6.22％和8.51％.(2)影响糖尿病发病的多因素logistic回归分析显示,校正年龄、性别等因素后,与第一分位组比较,第二分位组、第三分位组和第四分位组均增加新发糖尿病的发病风险,OR值分别为1.17、1.47和1.95.在不同性别人群中校正上述因素后,与第一分位组比较,第二分位组对不同性别人群的影响不再显著,但仍增加糖尿病的发病风险,男性OR值分别为1.08、1.36和1.90,女性为1.35、1.70和1.88.结论腰围增大增加糖尿病的发病风险.
목적 탐토중국북방인군중요위증가여당뇨병발병풍험지간적관계.방법 본연구채용전첨성대렬연구방법,이삼가2006～2007년도개란집단직공건강체검적101510명직공중공복혈당(FPG)＜7.0mmol/L、무당뇨병병사、미사용강당약물차FPG급요위자료완정적89364명직공작위관찰대렬,배제2010～2011년도미삼가체검자、FPG급요주자료결실자,최종납입통계분석적유효수거위58426명.의거기선요위측량치장관찰대상분위비반조여비비반조,비교2조문당뇨병적발병솔,동시의거기선요위사분위수장관찰대상분위4조,비교4조간당뇨병적발병솔.용다인소logistic회귀분석요위증가여2형당뇨병발병풍험적관계.결과 (1)비반조당뇨병발병솔고우비비반조(8.02％대3.37％,P＜0.01).수착요위적증가,당뇨병적발병솔축점승고,제일분위、제이분위、제삼분위화제사분위조적발병솔분별위2.32％、3.62％、5.46％화8.89％.안성별분층후,남성4조당뇨병적발병솔분별위2.84％、3.65％、5.32％화8.95％,녀성분별위1.50％、3.41％、6.22％화8.51％.(2)영향당뇨병발병적다인소logistic회귀분석현시,교정년령、성별등인소후,여제일분위조비교,제이분위조、제삼분위조화제사분위조균증가신발당뇨병적발병풍험,OR치분별위1.17、1.47화1.95.재불동성별인군중교정상술인소후,여제일분위조비교,제이분위조대불동성별인군적영향불재현저,단잉증가당뇨병적발병풍험,남성OR치분별위1.08、1.36화1.90,녀성위1.35、1.70화1.88.결론 요위증대증가당뇨병적발병풍험.
Objective To explore the relationship between the change in waist circumference (WC) and new onset diabetes (NOD) in a population of north China.Methods A total of 101510 subjects took part in the health examination from 2006 to 2007 for the employees of Kailuan Group.89364 subjects with fasting plasma glucose (FPG) ＜7.0 mmol/L,no history of diabetes,with complete data of FPG and WC,and without taking hypoglycemic agents were sclected as the observation cohort.Subjects who did not participate in the health examination from 2010 to 2011 and had incomplete data were finally excluded and thus 58426 subjects were included for final analysis.According to the baseline WC measurement and its quartile in the health examination during 2006 to 2007,the observed population was divided into two groups (obese group and non-obese group) or four groups ( first,second,third,and forth quartile groups).Multiple logistic regression analysis was used to test the relation between the change in WC and NOD.Results ( 1 ) The incidence of NOD in obese group was higher than that in non-obese group (8.02％ vs 3.37％,P＜0.01 ).Along with increasing WC in the 4 quartile groups,the incidence of NOD was progressively increased,being 2.32％,3.62％,5.46％,and 8.89％ respectively in the total population ( 2.84％,3.65％,5.32％,and 8.95％ in male,and 1.50％,3.41％,6.22％,and 8.51％ in female).( 2 ) Multiple logistic regression analysis showed that compared with the first quartile group,the second,third,and forth quartile groups had increased risks of NOD after adjusting age,gender,and other risk factors,the OR value being 1.17,1.47,and 1.95,respectively.After adjusting above factors in different genders,the influence of the second group on NOD in males and females was not significant,however,they still increased the risks of NOD,with the OR value being 1.08,1.36,and 1.90 in male,and 1.35,1.70,and 1.88 in female,respectively.Conclusion The incidence of NOD is increased with increasing WC.