CAJ | 학술논문

目的比较复方倍他米松注射液和醋酸曲安奈德注射液皮损内注射治疗活动期斑秃的临床疗效.方法将160例活动期斑秃患者随机分成两组,治疗组100例、对照组60例,治疗组用复方倍他米松注射液皮损内注射,对照组用醋酸曲安奈德注射液皮损内注射,每3周1次,12周后观察结果.结果治疗12周后治疗组痊愈60例(60.0%),显效32例(32.0%),总有效率92.0%;对照组痊愈25例(41.7%),显效19例(31.67%),总有效率73.3%;治疗组有效率和痊愈率显著高于对照组(χ2值分别为10.25和5.06,P<0.01和<0.05).治疗组出现局部头皮萎缩8例(8%),局部毛囊炎8例(8%);对照组出现局部头皮萎缩9例(15%),局部毛囊炎3例(5%),两组不良反应发生率比较,差异无统计学意义(P>0.05).结论复方倍他米松注射液皮损内注射治疗活动期斑秃疗效显著.
목적 비교복방배타미송주사액화작산곡안내덕주사액피손내주사치료활동기반독적림상료효.방법 장160례활동기반독환자수궤분성량조,치료조100례、대조조60례,치료조용복방배타미송주사액피손내주사,대조조용작산곡안내덕주사액피손내주사,매3주1차,12주후관찰결과.결과 치료12주후치료조전유60례(60.0%),현효32례(32.0%),총유효솔92.0%;대조조전유25례(41.7%),현효19례(31.67%),총유효솔73.3%;치료조유효솔화전유솔현저고우대조조(χ2치분별위10.25화5.06,P<0.01화<0.05).치료조출현국부두피위축8례(8%),국부모낭염8례(8%);대조조출현국부두피위축9례(15%),국부모낭염3례(5%),량조불량반응발생솔비교,차이무통계학의의(P>0.05).결론 복방배타미송주사액피손내주사치료활동기반독료효현저.
Objective To compare the clinical efficacy of intralesional betamethasone versus triamcinolone acetonide acetate in the treatment of active alopecia areata. Methods A total of 160 patients with active alopecia areata were divided into two groups, test group (n = 100) treated with intralesional betamethasone, and control group (n = 60) treated with intralesional triamcinolone acetonide. Both injections were given once every 3 weeks for 12 consecutive weeks. Results After 12-week treatment, the cure rate, response rate, and total response rate were 60.0%, 32.0% and 92.0% in the test group, respectively, compared to 41.7%, 31.67% and 73.3% in the control group, respectively. A significant increase was observed in the cure rate and response rate in the test group compared with the control group (χ2 = 10.25, 5.06, P < 0.01 and 0.05). During the treatment course, 8 (8%) patients in the test group and 9 (15%) patients in the control group developed localized atrophy of the scalp; 8 (8%) patients in the test group and 3 (5%) patients in the control group developed localized folliculitis; no significant difference was observed between the two groups in the occurrence of adverse reactions (P> 0.05). Conclusion Intralesional use of compound betamethasone injection has a notable therapeutic effect on alopecia areata.