CAJ | 학술논문

目的观察血清中可溶性CD20分子(sCD20)在肾移植急性排斥反应时的变化,探讨血清sCD20水平变化与移植肾预后的关系.方法收集50例肾移植患者外周血,酶联免疫吸附测定法检测血清中sCD20水平.结果 25例急性排斥反应患者术前血清sCD20为(1750.60±359.59) ng/L,与稳定组(936.96±181.71) ng/L比较,差异有统计学意义(P＜0.05)；移植术后急性排斥反应组血清sCD20为(2516.20 ±511.33) ng/L,与稳定组(988.40 ±215.78)ng/L比较,差异有统计学意义(P＜0.05)；而且sCD20值水平较高的患者移植肾存活时间明显少于sCD20值水平较低的患者.结论 CD20分子在移植肾急性排斥反应和预测肾移植预后中可能起重要作用.
목적 관찰혈청중가용성CD20분자(sCD20)재신이식급성배척반응시적변화,탐토혈청sCD20수평변화여이식신예후적관계.방법 수집50례신이식환자외주혈,매련면역흡부측정법검측혈청중sCD20수평.결과 25례급성배척반응환자술전혈청sCD20위(1750.60±359.59) ng/L,여은정조(936.96±181.71) ng/L비교,차이유통계학의의(P＜0.05)；이식술후급성배척반응조혈청sCD20위(2516.20 ±511.33) ng/L,여은정조(988.40 ±215.78)ng/L비교,차이유통계학의의(P＜0.05)；이차sCD20치수평교고적환자이식신존활시간명현소우sCD20치수평교저적환자.결론 CD20분자재이식신급성배척반응화예측신이식예후중가능기중요작용.
Objective To study the relationship between the expression of sCD20 and the graft acute rejection,and the relationship between the level of sCD20 in peripheral blood and prognosis of the transplant kidney.Methods Fifty patients who had received renal transplantation from 2007 to 2010 were retrospectively reviewed.The expression of sCD20 in the blood was detected by enzyme linked immunosorbent assay (ELISA).Results The expression levels of sCD20 were higher in acute renal rejection group (1750.60±359.59) ng/L than those in non-rejection group (936.96 ± 181.71 ) ng/L before transplantation (P ＜0.05).After transplantation the expression levels of sCD20 were (2516.20 ±511.33) ng/L in acute renal rejection group and (988.40 ± 215.78 ) ng/L in non-rejection group ( P ＜ 0.05 ).Conclusion The expression of sCD20 in blood is correlated with clinical renal acute rejection and prognosis of the transplant kidney.