国际皮肤性病学杂志
國際皮膚性病學雜誌
국제피부성병학잡지
INTERNATIONAL JOURNAL OF DERMATOLOGY AND VENEREOLOGY
2011年
3期
180-183
,共4页
神经梅毒%密螺旋体,苍白%脑脊液
神經梅毒%密螺鏇體,蒼白%腦脊液
신경매독%밀라선체,창백%뇌척액
Neurosyphilis%Treponema pallidum%Cerebrospinal fluid
神经梅毒的发生可能与梅毒螺旋体的神经侵袭性和宿主细胞免疫力有关,HIV感染会增加神经梅毒的发生率.脑脊液RPR检测可以作为性病研究实验室试验的替代方法用于神经梅毒的诊断,脑脊液中tau蛋白和趋化因子CXCL13检测对于神经梅毒的诊断也具有一定的提示意义.对于青霉素过敏者,可试用多西环素或头孢曲松作为替代药物.在驱梅治疗的基础上,辅助治疗可以起到改善症状和增加疗效的作用.血清RPR滴度的动态观测可试用于神经梅毒的疗效判断.
神經梅毒的髮生可能與梅毒螺鏇體的神經侵襲性和宿主細胞免疫力有關,HIV感染會增加神經梅毒的髮生率.腦脊液RPR檢測可以作為性病研究實驗室試驗的替代方法用于神經梅毒的診斷,腦脊液中tau蛋白和趨化因子CXCL13檢測對于神經梅毒的診斷也具有一定的提示意義.對于青黴素過敏者,可試用多西環素或頭孢麯鬆作為替代藥物.在驅梅治療的基礎上,輔助治療可以起到改善癥狀和增加療效的作用.血清RPR滴度的動態觀測可試用于神經梅毒的療效判斷.
신경매독적발생가능여매독라선체적신경침습성화숙주세포면역력유관,HIV감염회증가신경매독적발생솔.뇌척액RPR검측가이작위성병연구실험실시험적체대방법용우신경매독적진단,뇌척액중tau단백화추화인자CXCL13검측대우신경매독적진단야구유일정적제시의의.대우청매소과민자,가시용다서배소혹두포곡송작위체대약물.재구매치료적기출상,보조치료가이기도개선증상화증가료효적작용.혈청RPR적도적동태관측가시용우신경매독적료효판단.
The development of neurosyphilis may be associated with Treponema pallidum neuroinvasion and host immunity. Human immunodeficiency virus (HIV) infection may increase the incidence of neurosyphilis. Cerebrospinal fluid (CSF)-rapid plasma reagent (RPR) test can be applied as a substitute for venereal disease research laboratory test (VDRL) to the diagnosis of neurosyphilis. Detection of tau protein and chemokine CXCL13 in CSF also has great value in the diagnosis of neurosyphilis. For patients allergic to penicillin, doxycycline or ceftriaxone may serve as alternative drugs. Adjuvant therapy may benefit the improvement of syphilis symptoms and strengthen the efficacy of antisyphilitic treatment. Dynamic observation of serum RPR titer can be used to monitor the treatment efficacy in patients with neurosyphilis.
