中国基层医药
中國基層醫藥
중국기층의약
CHINESE JOURNAL OF PRIMARY MEDICINE AND PHARMACY
2011年
10期
1345-1347
,共3页
劳丹华%潘志坚%黄剑娴%梁深
勞丹華%潘誌堅%黃劍嫻%樑深
로단화%반지견%황검한%량심
糖尿病,妊娠%C反应蛋白%胰岛素抵抗
糖尿病,妊娠%C反應蛋白%胰島素牴抗
당뇨병,임신%C반응단백%이도소저항
Diabetes mellitus,gestational%C-reactive protein%Insulin resistance
目的 探讨妊娠期糖尿病(GDM)患者血清超敏C反应蛋白(hs-CRP)与胰岛β细胞功能的关系.方法 选择60例GDM孕妇作为观察组(GDM组),同时选择30例糖耐量正常的孕妇作为对照组(NGT组),测定hs-CRP水平,同时计算稳态模型胰岛素抵抗指数(HOMA-IR)和胰岛素分泌指数(HOMA-β).结果 GDM组的hs-CRP和HOMA-IR显著高于NGT组(P＜0.01),而HOMA-β显著低于NGT组(P＜0.05).hs-CRP与年龄、孕前BMI、筛查时BMI、空腹血糖(FBG)、空腹胰岛素(Flns)和HOMA-IR显正相关(r=0.222,0.649,0.862,0.923,0.935,0.941,P＜0.05或P＜0.01),与HOMA-β呈负相关(r=-0.872,P＜0.01).多元逐步回归分析显示,HOMA-IR和HOMA-β是影响hs-CRP最为显著的因素.结论 GDM 患者血清hs-CRP水平明显升高与胰岛素抵抗(IR)及胰岛细胞分泌功能密切相关,可能参与GDM的发生和发展.
目的 探討妊娠期糖尿病(GDM)患者血清超敏C反應蛋白(hs-CRP)與胰島β細胞功能的關繫.方法 選擇60例GDM孕婦作為觀察組(GDM組),同時選擇30例糖耐量正常的孕婦作為對照組(NGT組),測定hs-CRP水平,同時計算穩態模型胰島素牴抗指數(HOMA-IR)和胰島素分泌指數(HOMA-β).結果 GDM組的hs-CRP和HOMA-IR顯著高于NGT組(P＜0.01),而HOMA-β顯著低于NGT組(P＜0.05).hs-CRP與年齡、孕前BMI、篩查時BMI、空腹血糖(FBG)、空腹胰島素(Flns)和HOMA-IR顯正相關(r=0.222,0.649,0.862,0.923,0.935,0.941,P＜0.05或P＜0.01),與HOMA-β呈負相關(r=-0.872,P＜0.01).多元逐步迴歸分析顯示,HOMA-IR和HOMA-β是影響hs-CRP最為顯著的因素.結論 GDM 患者血清hs-CRP水平明顯升高與胰島素牴抗(IR)及胰島細胞分泌功能密切相關,可能參與GDM的髮生和髮展.
목적 탐토임신기당뇨병(GDM)환자혈청초민C반응단백(hs-CRP)여이도β세포공능적관계.방법 선택60례GDM잉부작위관찰조(GDM조),동시선택30례당내량정상적잉부작위대조조(NGT조),측정hs-CRP수평,동시계산은태모형이도소저항지수(HOMA-IR)화이도소분비지수(HOMA-β).결과 GDM조적hs-CRP화HOMA-IR현저고우NGT조(P＜0.01),이HOMA-β현저저우NGT조(P＜0.05).hs-CRP여년령、잉전BMI、사사시BMI、공복혈당(FBG)、공복이도소(Flns)화HOMA-IR현정상관(r=0.222,0.649,0.862,0.923,0.935,0.941,P＜0.05혹P＜0.01),여HOMA-β정부상관(r=-0.872,P＜0.01).다원축보회귀분석현시,HOMA-IR화HOMA-β시영향hs-CRP최위현저적인소.결론 GDM 환자혈청hs-CRP수평명현승고여이도소저항(IR)급이도세포분비공능밀절상관,가능삼여GDM적발생화발전.
Objective To explore the correlation between serum hs-CRP and β-cell finction in patients with gestational diabetes mellitus(GDM).Methods The levels of hs-CRP in 60 patients with GDM(GDM group)and 30pregnant women with normal glucose tolerance(NGT group)were detected.Insulin resistance was assessed by the homeostasismodel insulin resistance index(HOMA-IR),Insulin secretion by the homeostasis β-cell funetiOn index(HOMA-β).Results The levels of hs-CRP and HOMA-IR were higher in GDM group than in NGT group.There was significant difference between two groups(P＜0.01);HOMA-β was lower in GDM group than in NGT group,there was significant difference between two groups(P＜0.05).The level of hs-CRP was correlated with age,pre-pregnant bodymass-index(BMI),screening BMI,fasting blood glucose(FBG),fasting insulin(Fins),and HOMA-IR(r=0.222,0.649、0.862、0.923、0.935、0.941,P＜0.05 or P＜0.01),but was inversely related with HOMA-β(r=-0.872,P＜0.01).Multiple stepwise regression analysis indicated that HOMA-IR and HOMA-β was the most important effect factors of hs-CRP.Conclusion The level of hs-CRP increased in women with GDM.which was related to insulin resistance(IR)and insulin secretion,and it maybe participate in the pathogenesis of GDM.
