CAJ | 학술논문

目的探讨脓疱性银屑病患者经阿维A治疗前后外周血中白介素8(IL-8)水平的变化.方法用双抗体夹心法(ELISA)检测患者治疗前、后外周血白介素(IL-8)的水平并与正常人进行比较,进一步评价IL-8与脓疱性银屑病病情的相关性.结果阿维A在改善脓疱性银屑病患者病情的同时,外周血IL-8的水平(治疗前96.84±14.68 pg/ml,治疗后57.07±12.02 pg/ml)显著下降,差异有统计学意义(P均＜ 0.05).结论阿维A下调IL-8水平可能是其治疗脓疱性银屑病的作用机制之一.
목적 탐토농포성은설병환자경아유A치료전후외주혈중백개소8(IL-8)수평적변화.방법 용쌍항체협심법(ELISA)검측환자치료전、후외주혈백개소(IL-8)적수평병여정상인진행비교,진일보평개IL-8여농포성은설병병정적상관성.결과 아유A재개선농포성은설병환자병정적동시,외주혈IL-8적수평(치료전96.84±14.68 pg/ml,치료후57.07±12.02 pg/ml)현저하강,차이유통계학의의(P균＜ 0.05).결론 아유A하조IL-8수평가능시기치료농포성은설병적작용궤제지일.
Objective To investigate the changes of IL-8 in peripheral blood of patients with pustular psoriasis after acitretin treatment.Methods Dual antibody sandwich enzyme-linked immunosorbent assay (ELISA)was performed to measure the IL-8 levels in the peripheral blood of 30 patients with pustular psoriasis and 30 patients with psoriasis vulgaris before and after treatment,and in 30 normal human controls.The relationship between the IL-8 level and disease severity was assessed for patients with pustular psoriasis.Results After acitretin treatment,the condition was improved greatly in patients with pustular psoriasis,together with a significant decrease in the level of IL-8 in the peripheral blood(57.07 ± 12.02 pg/ml vs.96.84 ± 14.68 pg/ml,P ＜ 0.05).Conclusion IL-8 may be involved in the therapeutic mechanism of acitretin in pustular psoriasis.