CAJ | 학술논문

目的:为了实现较深层组织内微血管的光声成像.方法:采用波长532 nm、重复频率10 Hz的脉冲激光作为激励源,宽带非聚焦针状探头以圆周扫描的方式采集时域光声信号,二维光学吸收分布图像由时域后向投影算法重建,以线扩展函数为依据测量系统的成像空间分辨率.结果:成像空间分辨率0.1 mm,模拟微血管网络的光声图像与原始样品完全吻合.结论:对组织内癌症病灶的早期诊断具有较大的意义.
목적:위료실현교심층조직내미혈관적광성성상.방법:채용파장532 nm、중복빈솔10 Hz적맥충격광작위격려원,관대비취초침상탐두이원주소묘적방식채집시역광성신호,이유광학흡수분포도상유시역후향투영산법중건,이선확전함수위의거측량계통적성상공간분변솔.결과:성상공간분변솔0.1 mm,모의미혈관망락적광성도상여원시양품완전문합.결론:대조직내암증병조적조기진단구유교대적의의.
Objectieve:In order to get the photoacoustic (PA) image of micro-blood vessel deep inside biological tissue.Materials and Methods:A 532nm pulse laser with the repetition rate of 10Hz was used as the pumping source.A wide band unfocused needle ultrasound transducer was used to collect time-domain PA signal of the tissue-mimicking phantom by circular scan.The 2D optical absorption image was reconstructed by time-domain spherical back projection algorithm.The spatial resolution was measured by line-spread-function(LSF).Results:The experimental results demonstrated that the spatial resolution was 0.1 mm and the PA image of the micro-vascular network agreed well with the tissue-mimicking phantom.Conclusion:The proposed method is valuable for the diagnosis of early cancer inside tissue.