国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2008年
11期
663-666
,共4页
慢性阻塞性肺疾病%肺血管%非低氧时期%超微结构
慢性阻塞性肺疾病%肺血管%非低氧時期%超微結構
만성조새성폐질병%폐혈관%비저양시기%초미결구
Chronic obstructive pulmonary disease%Pulmonary vascular%Non-hypoxic period%Ultrastructlaral
近年来研究发现,肺功能正常的吸烟者已出现肺血管功能的异常及结构改变.电镜下可观察到内皮细胞的细胞器损伤及功能异常,血管内膜增厚,肺血管肌化;血管周围炎症反应等.这些改变与肺动脉高压的发生密切相关,而吸烟和炎症可能为其重要的影响因素.其理论的深入研究及阐明,对早期防治慢性阻塞性肺疾病的肺动脉重建有重要意义.
近年來研究髮現,肺功能正常的吸煙者已齣現肺血管功能的異常及結構改變.電鏡下可觀察到內皮細胞的細胞器損傷及功能異常,血管內膜增厚,肺血管肌化;血管週圍炎癥反應等.這些改變與肺動脈高壓的髮生密切相關,而吸煙和炎癥可能為其重要的影響因素.其理論的深入研究及闡明,對早期防治慢性阻塞性肺疾病的肺動脈重建有重要意義.
근년래연구발현,폐공능정상적흡연자이출현폐혈관공능적이상급결구개변.전경하가관찰도내피세포적세포기손상급공능이상,혈관내막증후,폐혈관기화;혈관주위염증반응등.저사개변여폐동맥고압적발생밀절상관,이흡연화염증가능위기중요적영향인소.기이론적심입연구급천명,대조기방치만성조새성폐질병적폐동맥중건유중요의의.
Recent studies have found that there have been abnormal pulmonary vascular function and changes in the structure of normal lung function smokers.By electron microscope,we can observe that the injurv and dysfunction of the endothelial cells,as well as the thickening of intima,proliferation of collagen matrix.perivascular inflammatory reaction.These changes are closely related to pulmonary hypertension,and probabily smoking and inflammatory are the two vital influencing factors.The in-depth study of these theories will be a great significance for early prevention and treatment of chronic obstructive pulmonary disease and pulmonary artery reconstruction.
