CAJ | 학술논문

目的探讨鼻咽癌放射治疗后诱发的第二恶性肿瘤的临床特点.方法回顾分析28例鼻咽痛患者因放射诱发的第二原发性恶性肿瘤的临床资料.结果本组28例患者中,鳞状上皮癌16例,占57.1%;肉瘤类5例,占17.9%;腺样囊性癌3例,占10.7%;基底细胞癌3例,占10.7%;恶性黑色素瘤1例,占3.6%.经手术治疗20例,3年生存率75%,5年生存率35%;放疗结合化疗的3年生存率25%;单纯放疔或化疗的,均于2年内死亡.结论放射诱发的第二原发性恶性肿瘤如具备手术适应证,则应首选手术或包含手术的综合治疗.积极治疗第二原发性恶性肿瘤同样可以获得较好的治疗效果.
목적 탐토비인암방사치료후유발적제이악성종류적림상특점.방법 회고분석28례비인통환자인방사유발적제이원발성악성종류적림상자료.결과 본조28례환자중,린상상피암16례,점57.1%;육류류5례,점17.9%;선양낭성암3례,점10.7%;기저세포암3례,점10.7%;악성흑색소류1례,점3.6%.경수술치료20례,3년생존솔75%,5년생존솔35%;방료결합화료적3년생존솔25%;단순방정혹화료적,균우2년내사망.결론 방사유발적제이원발성악성종류여구비수술괄응증,칙응수선수술혹포함수술적종합치료.적겁치료제이원발성악성종류동양가이획득교호적치료효과.
Objective To investigate the clinical characteristics of second primary carcinoma induced by radiation therapy in patients with nasopharyngeal carcinoma. Methods A retrospective analysis was carried out to investigate the clinical data of radiation-induced second primary carcinoma in 28 cases with nasopharyngeal carcinoma. Results Among 28 cases, 16 (57.1%) cases presented squamous cell carcinoma; 5 (17.9%) cases presented sarcoma; 3 (10.7%) presented adenoid cystic carcinoma; another 3 (10.7%) presented basal cell carcinoma; and 1( 3.6%)presented malignant melanoma. In 20 cases that accepted surgical treatment, the 3-year, and 5-year survival rate were 75% and 35%; the 3-year survival rate after radiation therapy combined with chemotherapy was 25%; those with only radiotherapy or chemotherapy were all dead in 2 years. Conclusions If a patient with radiation-induced second primary carcinoma has an indication for surgery, it' s better to use treatment such as surgery or comprehensive treatment. The positive treatment to second primary carcinoma can also get good curative effect.