CAJ | 학술논문

目的探讨大光斑低能量Q开关Nd∶YAG激光治疗黄褐斑的疗效,分析黄褐斑皮损激光治疗前后共聚焦激光扫描显微镜(CLSM)特征.方法收集45例黄褐斑患者,使用大光斑低能量调Q开关Nd∶YAG 1064 nm激光治疗,并在治疗前后对其行CLSM检查.结果 45例患者,治疗结束后基本治愈8例(17.78％),显效25例(55.56％),好转11例(24.44％),无效1例(2.22％),有效率为73.33％.CLSM下可见黄褐斑皮损处较周围正常皮损处表皮全层黑素颗粒增多,激光治疗后表皮处黑素颗粒显著减少.结论大光斑低能量调Q 1064 nm激光治疗黄褐斑疗效确切,安全性高,CLSM可用于判断激光治疗疗效.
목적 탐토대광반저능량Q개관Nd∶YAG격광치료황갈반적료효,분석황갈반피손격광치료전후공취초격광소묘현미경(CLSM)특정.방법 수집45례황갈반환자,사용대광반저능량조Q개관Nd∶YAG 1064 nm격광치료,병재치료전후대기행CLSM검사.결과 45례환자,치료결속후기본치유8례(17.78％),현효25례(55.56％),호전11례(24.44％),무효1례(2.22％),유효솔위73.33％.CLSM하가견황갈반피손처교주위정상피손처표피전층흑소과립증다,격광치료후표피처흑소과립현저감소.결론 대광반저능량조Q 1064 nm격광치료황갈반료효학절,안전성고,CLSM가용우판단격광치료료효.
Objective To evaluate the effect of large-spot and low-energy Q switched Nd:YAG laser on melasma,and to observe the changes of melasma lesions with confocal laser scanning microscopy (CLSM) before and after the laser treatment.Methods Totally,45 patients aged from 24 to 48 years and diagnosed with facial melasma were included in this study,and treated with large-spot and low-energy Q switched Nd:YAG once a week for 10 or more sessions.CLSM was used to estimate the melanin content in melasma lesions before each irradiation and after the last irradiation.Results Among the 45 patients,8 ( 17.78％ ) were nearly cured,25 (55.56％) markedly improved,11 (24.44％) improved,and only 1 (2.22％) unimproved after the laser irradiation.The total response rate was 73.33％.As CLSM showed,there was an increment in melanin granules in melasma lesions compared with the normal skin surrounding melasma lesions,but a reduction in melanin granules was induced by the laser treatment in melasma lesions.Conclusions Large-spot and lowenergy Q switched Nd∶YAG laser is substantially effective and highly safe for the treatment of melasma,and CLSM can be used to evaluate the therapeutic effect of laser on melasma.