CAJ | 학술논문

目的分析伴有t(7;11)(p15;p15)的急性髓系白血病(AML)患者的临床和实验室特征.方法对11例伴有t(7;11)(p15;p15)的AML患者进行回顾性分析,包括细胞形态学、细胞免疫表型、细胞遗传学和临床预后.结果 11例患者中8例为女性,AML-M2a6例,M4、M5各2例,M61例.11例患者均表达CD33,其中10例表达CD117、CD13,7例表达HLA-DR,6例表达CD34.11例患者染色体核型均显示有t(7;11)(p15;p15),其中1例伴有+8.共9例患者检测FLT3-ITD、TKD突变,其中1例FLT3-ITD突变阳性.11例患者仅2例存活,1例失访;其余8例均死亡.结论 t(7;11)(p15;p15)异常是一种少见的染色体易位,伴有该异常的AML患者具有贫血、血小板减少、白细胞升高的临床特征,预后不良.
목적 분석반유t(7;11)(p15;p15)적급성수계백혈병(AML)환자적림상화실험실특정.방법 대11례반유t(7;11)(p15;p15)적AML환자진행회고성분석,포괄세포형태학、세포면역표형、세포유전학화림상예후.결과 11례환자중8례위녀성,AML-M2a6례,M4、M5각2례,M61례.11례환자균표체CD33,기중10례표체CD117、CD13,7례표체HLA-DR,6례표체CD34.11례환자염색체핵형균현시유t(7;11)(p15;p15),기중1례반유+8.공9례환자검측FLT3-ITD、TKD돌변,기중1례FLT3-ITD돌변양성.11례환자부2례존활,1례실방;기여8례균사망.결론 t(7;11)(p15;p15)이상시일충소견적염색체역위,반유해이상적AML환자구유빈혈、혈소판감소、백세포승고적림상특정,예후불량.
Objective To investigate clinical and laboratory characteristics of acute myeloid leukemia (AML) patients with t(7;11)(p15;p15).Methods Eleven patients with t(7;11)(p15;p15) were retrospectively reviewed involved in cell morphology, immunophenotype, cytogenetics as well as clinical features and prognosis.Results Eight patients out of the eleven were female, six patients were AML-M2a, two M4,two M5, and one M6.All the 11 cases expressed CD33, 10 expressed CD117 and CD13, HLA-DR and CD34 was expressed in 7 and 6 patients, respectively.Karyotypes of all the patients were t ( 7; 11 ) ( p15; p15 ), additional trisomy 8 were found in only one patient.FLT3-ITD was positive in one of nine patients who were analysed for FLT3-ITD and FLT3-TKD.Two patients were alive, and one lost to followed up, while the rest of eight were dead.Conclusion The t(7;1 I )(p15;p15) abnormalities is one of rare chromosomal translocation in patients with AML.AML patients with t(7; 11 ) ( p15 ;p15 ) have clinical features of anemia, thrombocytopenia, higher white blood cell, and poor prognosis.