CAJ | 학술논문

目的探讨青少年空腹血浆Ghrelin水平改变及其意义.方法选取2006年秦皇岛市青少年肥胖与代谢综合征流行病学调查对象共4604人,排除近期有急慢性炎症个体.通过查取随机数字表,从中随机选取13～15岁青少年158名,根据Ghrelin中位数分为2组各79例:A组(Ghrelin ＜1336.9 ng/L),B组(Ghrelin≥1336.9 ng/L),测量身高、体质量及腰围(WC).空腹静脉采血,测量血糖、真胰岛素(true insulin,TI)和ghrelin水平,计算胰岛素抵抗指数.组间比较采用t检验,相关分析采用Pearson相关,多因素分析应用多元线性回归.结果 (1)A组空腹血糖(FPG)、TI和胰岛素抵抗指数(HOMA-IR)高于B组(P＜0.05),两组体质指数(BMI)和WC比较差异无统计学意义(P＞0.05).(2)Ghrelin与FPG(r=-0.367,P=0.000)和In(HOMA-IR)(r=-0.196,P＜0.05)存在单变量相关.多元线性回归显示,以Ghrelin为因变量,FPG(β=-337.2,P=0.000)和ln(HOMA-IR)(β=-160.0,P＜0.05)被引入方程.结论青少年空腹血浆Ghrelin水平降低与FPG升高和胰岛素抵抗密切相关.Ghrelin水平降低可能是青少年糖代谢异常的保护因素.
목적 탐토청소년공복혈장Ghrelin수평개변급기의의.방법 선취2006년진황도시청소년비반여대사종합정류행병학조사대상공4604인,배제근기유급만성염증개체.통과사취수궤수자표,종중수궤선취13～15세청소년158명,근거Ghrelin중위수분위2조각79례:A조(Ghrelin ＜1336.9 ng/L),B조(Ghrelin≥1336.9 ng/L),측량신고、체질량급요위(WC).공복정맥채혈,측량혈당、진이도소(true insulin,TI)화ghrelin수평,계산이도소저항지수.조간비교채용t검험,상관분석채용Pearson상관,다인소분석응용다원선성회귀.결과 (1)A조공복혈당(FPG)、TI화이도소저항지수(HOMA-IR)고우B조(P＜0.05),량조체질지수(BMI)화WC비교차이무통계학의의(P＞0.05).(2)Ghrelin여FPG(r=-0.367,P=0.000)화In(HOMA-IR)(r=-0.196,P＜0.05)존재단변량상관.다원선성회귀현시,이Ghrelin위인변량,FPG(β=-337.2,P=0.000)화ln(HOMA-IR)(β=-160.0,P＜0.05)피인입방정.결론 청소년공복혈장Ghrelin수평강저여FPG승고화이도소저항밀절상관.Ghrelin수평강저가능시청소년당대사이상적보호인소.
Objective To evaluate the variation of fasting plasma ghrelin and its implication in adolescents. Methods In 2006,the study included 158 adolescents aged 13 to 15 years in Qinhuangdao. They were divided into two groups: group A( n = 79,Ghrelin ＜ 1336. 9 ng/L) and group B (n= 79,Ghrelin ≥ 1336.9 ng/L). Anthropometric measurements including height,weight and waist circumference ( WC ). Blood samples were collected and fasting plasma glucose ( FPG),true insulin ( TI ),and Ghrelin were assayed. The methods used for analysis were t test,Pearson correlation and multiple linear regression. Results (1) Group A had significantly higher levels of FPG,TI,insulin resistance index (HOMA-IR) than group B (P＜0. 05 ). Body mass index(BMI) and WC showed no significant difference between two groups ( P ＞ 0. 05 ). ( 2 ) Ghrelin showed negative correlation with FPG ( r = - O. 367,P =0. 000) and In(HOMA-IR) ( r = -0. 196,P ＜ 0. 05 ). In multiple regression analyses,FPG( β = - 337. 2,P =0. 000) and In (HOMA-IR) ( β = - 160. 0,P ＜ 0. 05 ) were consistently associated with ghrelin.Conclusions Ghrelin correlated with FPG and HOMA-IR. The data suggests that the lower Ghrelin level may be a protective factor in adolescent with abnormal glucose metabolism.