CAJ | 학술논문

目的研究急性期视神经脊髓炎患者血清尿酸水平和临床特点的关系.方法尿酸酶-过氧化物酶耦联法检测65例视神经脊髓炎患者与对照组76例多发性硬化,126例脑血管病,130例健康者的血清尿酸水平.视神经脊髓炎组采用扩展残疾状态量表评价疾病严重程度,行核磁并强化评估受累病灶,细胞免疫荧光法检测水通道蛋白(AQ)P4抗体.分析尿酸与病程、疾病轻重、受累病灶、AQP4等临床特点的相关性.结果男性视神经脊髓炎组尿酸[(298.90±74.14)μmol/L]显著低于脑血管病组[(355.37±50.30)μ.mol/L]和对照组[(340.33±58.23)μmol/L,P＜0.05],与多发性硬化组[(292.36±92.95)μmol/L]差异无统计学意义.女性视神经脊髓炎组尿酸[(198.21±62.62)μmol/L]显著低于脑血管病组[(274.51±70.66)μmol/L]和对照组[(243.26±60.65)μmol/L,P＜0.05],与多发性硬化组[(232.29±71.95)μmol/L]差异无统计学意义.视神经脊髓炎组尿酸在男性[(298.90 ±74.14)μmol/L]与女性[(198.21±62.62)μmol/L]、扩展残疾状态量表评分＞5分[(195.48±83.70)μmol/L]与＜5分[(241.00±63.20)μmol/L]的患者相比差异有统计学意义(P＜0.05),与病程、脊髓受累节段、病灶强化,AQP4阳性无关(P＞0.05).结论急性期视神经脊髓炎患者血清尿酸降低,并且与疾病严重程度有关.
목적 연구급성기시신경척수염환자혈청뇨산수평화림상특점적관계.방법 뇨산매-과양화물매우련법검측65례시신경척수염환자여대조조76례다발성경화,126례뇌혈관병,130례건강자적혈청뇨산수평.시신경척수염조채용확전잔질상태량표평개질병엄중정도,행핵자병강화평고수루병조,세포면역형광법검측수통도단백(AQ)P4항체.분석뇨산여병정、질병경중、수루병조、AQP4등림상특점적상관성.결과 남성시신경척수염조뇨산[(298.90±74.14)μmol/L]현저저우뇌혈관병조[(355.37±50.30)μ.mol/L]화대조조[(340.33±58.23)μmol/L,P＜0.05],여다발성경화조[(292.36±92.95)μmol/L]차이무통계학의의.녀성시신경척수염조뇨산[(198.21±62.62)μmol/L]현저저우뇌혈관병조[(274.51±70.66)μmol/L]화대조조[(243.26±60.65)μmol/L,P＜0.05],여다발성경화조[(232.29±71.95)μmol/L]차이무통계학의의.시신경척수염조뇨산재남성[(298.90 ±74.14)μmol/L]여녀성[(198.21±62.62)μmol/L]、확전잔질상태량표평분＞5분[(195.48±83.70)μmol/L]여＜5분[(241.00±63.20)μmol/L]적환자상비차이유통계학의의(P＜0.05),여병정、척수수루절단、병조강화,AQP4양성무관(P＞0.05).결론 급성기시신경척수염환자혈청뇨산강저,병차여질병엄중정도유관.
Objective To investigate serum uric acid (UA) levels and related clinical characteristics of neuromyelitis optica (NMO). Methods The serum uric acid levels were measured in 65 patients with NMO, compared to control groups which were 76 cases with multiple sclerosis ( MS), 126 cases with cerebral vascular diseases (CVD) and 130 healthy controls(HC). The disability severity in NMO was assessed by the Expanded Disability Status Scale (EDSS). Magnetic resonance imaging ( MRI ) was performed to strengthen assessment the involved lesions. Serum AQP4 antibody was tested in a cell based immunofluorescence assay. Results In male groups, serum UA levels in NMO patients [ (298.90±74.14) μmol/L] were significantly lower than that in CVD [ (355.37 ±50. 30) μmol/L] and HC subjects [ (340.33 ± 58.23 ) μmol/L, P ＜ 0.05 ]. No difference was found between NMO and MS [ ( 292.36 ±92.95) μmol/L] groups. In female groups, serum UA levels in NMO patients [(198.21 ± 62.62)μmol/L] were significantly lower than that in CVD [(274.51 ± 70.66) μmol/L] and HC subjects [(243.26 ±60.65) μmol/L,P ＜0.05]. No difference was found between NMO and MS [(232.29 ±71.95 ) μmol/L ] groups. UA levels were significantly lower in females [ ( 198.21 ± 62. 62) μ mol/L] than in males [ (298.90 ±74.14) μmol/L]. UA levels were significantly lower in patients with EDSS≥5 [ ( 195.48 ± 83.70 )μmol/L] than EDSS ＜ 5 [ (241.00 ± 63.20)μmol/L] NMO patients. In our study UA levels were not correlated with longitude of spinal lesions, activity revealed by MRI and AQP4 antibody tires.Conclusion Lower serum UA levels were found in patients with NMO and related to more severe symptoms.