CAJ | 학술논문

背景 μ、κ、δ、ε、σ及λ等多种阿片受体广泛存在于体内各器官,它们各自有其特异的内源性配体,发挥不同的生物效应,其对缺血/再灌注损伤(ischemia/reperfusion injury,I/RI)器官的保护作用已引起医学界的广泛关注.目的综述阿片受体激动剂对I/RI器官的保护作用的研究进展.内容阿片受体激动剂可模拟缺血预处理(ischemic preconditioning,IPC),减轻缺血/再灌注(ischemia/reperfusion,I/R)对心脏、脑、肝脏和肾脏等器官的损伤程度,保护缺血后器官的功能.趋向阿片受体激动剂预处理对I/R器官的保护作用研究已取得一定的进展,为IPC的研究提供了新思路,但目前仍停留于动物实验阶段,其具体机制和疗效有待于进一步的临床实践应用证实.
배경 μ、κ、δ、ε、σ급λ등다충아편수체엄범존재우체내각기관,타문각자유기특이적내원성배체,발휘불동적생물효응,기대결혈/재관주손상(ischemia/reperfusion injury,I/RI)기관적보호작용이인기의학계적엄범관주.목적 종술아편수체격동제대I/RI기관적보호작용적연구진전.내용 아편수체격동제가모의결혈예처리(ischemic preconditioning,IPC),감경결혈/재관주(ischemia/reperfusion,I/R)대심장、뇌、간장화신장등기관적손상정도,보호결혈후기관적공능.추향 아편수체격동제예처리대I/R기관적보호작용연구이취득일정적진전,위IPC적연구제공료신사로,단목전잉정류우동물실험계단,기구체궤제화료효유대우진일보적림상실천응용증실.
Background A large number of opioid receptors,such as μ receptor,κ receptor,δ receptor,ε receptor,σ receptor and λ receptor exist in various organs widely.Each of them has their own endogenous ligand and functions respectively.Its protective effects in ischemia/reperfusion(I/R)-induced organ injury have aroused wide attention in medical field.Objective This review introduces the new progress on the protective effects of pharmacological preconditioning with opioid receptor agonists in I/R-induced organ injury.Content Opioid receptor agonists have been proved to simulate ischemic preconditioning(LPC),attenuate the degree of ischemia/reperfusion injury(I/RI)and protect many organs' functions,such as heart,brain,liver,kidney and so on.Trend Study of opioid receptors on protective effects in I/R-induced organ injury has made some progress.It provides a new method for study on IPC.However,these studies were still based on animal experiments at present.More clinical practices are needed to prove the mechanisms and effects of opioid receptor agonists.