CAJ | 학술논문

目的观察生肌玉红汤纱布湿敷对血汞含量的影响,探讨含汞制剂中药的用药安全.方法选择32只兔子,雌雄各半,在背部建立慢性溃疡模型,随机分为两组,每组16只,一组为阴性对照组,用生理盐水纱布湿敷,另一组用生肌玉红汤纱布湿敷;分别用酸性氯化亚锡还原-冷原子吸收光谱法测定其血液中不同时间的汞含量.结果生肌玉红汤湿敷组中血汞的含量随着时间的延长不断增加,至第四周未时其浓度为(92.68±8.0)nmol/L,明显高于阴性对照组(83.05±8.8)nmol/L,两组比较差异有极显著性(P＜0.01).结论在创面使用含汞制剂的中药时应控制用药的时间,不宜超过1个月,以免发生汞中毒.
목적 관찰생기옥홍탕사포습부대혈홍함량적영향,탐토함홍제제중약적용약안전.방법 선택32지토자,자웅각반,재배부건립만성궤양모형,수궤분위량조,매조16지,일조위음성대조조,용생리염수사포습부,령일조용생기옥홍탕사포습부;분별용산성록화아석환원-랭원자흡수광보법측정기혈액중불동시간적홍함량.결과 생기옥홍탕습부조중혈홍적함량수착시간적연장불단증가,지제사주미시기농도위(92.68±8.0)nmol/L,명현고우음성대조조(83.05±8.8)nmol/L,량조비교차이유겁현저성(P＜0.01).결론 재창면사용함홍제제적중약시응공제용약적시간,불의초과1개월,이면발생홍중독.
Objective To observe the effect of wet dressing with shengji yuhong decoction on blood mercury level in rabbits, and to explore the safety of Chinese herbal formulas containing mercury.Methods A animal model of chronic back ulcers was established in 32 rabbits. The rabbits were then randomized to receive wet dressing with either normal saline (16 rabbits, control group), or shengji yuhong decoction (16 rabbits, decoction group). Blood mercury levels were detected by acidic stannous chloride deoxidation and cold atomic absorption spectrography at different time points. Results Blood mercury level increased in the decoction group with time and was significantly higher in the decoction group than in the control group at the end of the fourth week [(92.68 ± 8.0 ) nmol/L vs. ( 83.05 ± 8.8 ) nmol/L, P＜0.01].Conclusions The duration of application of Chinese herbal medicine containing mercury on wound should be limited.