CAJ | 학술논문

介绍应用对数线性模型分析病例-父母对照研究设计的方法.以亚甲基四氢叶酸还原酶基因(MTHFR)C677T与唇腭裂的关联研究为例,应用对数线性模型分析母亲、子代基因及其交互作用与唇腭裂的关系.结果显示变异型纯合子母亲的子代发生唇腭裂的风险低于野生型纯合子母亲的子代,S2=0.43 (95％CI:0.19 ～ 0.95),未发现唇腭裂与子代基因及母子交互作用相关.应用对数线性模型分析病例-父母对照研究设计的方法尤其适用于妊娠期疾病与源于胚胎时期疾病等的病因学研究.
개소응용대수선성모형분석병례-부모대조연구설계적방법.이아갑기사경협산환원매기인(MTHFR)C677T여진악렬적관련연구위례,응용대수선성모형분석모친、자대기인급기교호작용여진악렬적관계.결과현시변이형순합자모친적자대발생진악렬적풍험저우야생형순합자모친적자대,S2=0.43 (95％CI:0.19 ～ 0.95),미발현진악렬여자대기인급모자교호작용상관.응용대수선성모형분석병례-부모대조연구설계적방법우기괄용우임신기질병여원우배태시기질병등적병인학연구.
We were introducing a log-linear model for case-parent triad study.Data from a previous study of the association between MTHFR C677T aud cleft lip with or without cleft palate (CL/P) was analyzed,in order to investigate the maternal effect,fetal effect and their interaction,using a series of log-linear models.Our results showed that mothers who were carrying two copies of MTHFR C677T variant alleles appeared to have reduced the risk of CL/P in offspring,comparing to those with homozygous of wild-type allele.With S2=0.43 (95％ CI:0.19-0.95).No significant association was found for fetal genotype and maternal-fetal iuteraction with CL/P.Log-linear model method seemed to be useful in the estimation of maternal effect,fetal effect and maternal-fetal interaction,in the case-parent triad study design.This approach showed specific benefit in studies that related to genetic effects on complex diseases such as pregnancy complications and diseases originated from fetus.