CAJ | 학술논문

目的探讨凉润通络方及其拆方对糖尿病大鼠胃肠运动功能改善的机制.方法雄性Wistar大鼠,注射链脲佐菌素(STZ)制作糖尿病大鼠模型.造模成功后,不予降糖药控制血糖,正常饲养18周后,大鼠分别予温水、凉润通络中药、单纯通络中药、单纯滋润中药、单纯清凉中药、西沙必利灌胃,6周后检测血浆中胃动素(MOT)、胆囊收缩素(CCK)、生长抑素(SS).结果 24周时糖尿病大鼠存在胃肠激素的紊乱,凉润通络方影响血液中胃肠激素的分泌和释放,作用靶点较宽,优于其拆方和西沙必利.结论凉润通络方可改善糖尿病大鼠胃肠功能障碍.
목적 탐토량윤통락방급기탁방대당뇨병대서위장운동공능개선적궤제.방법 웅성Wistar대서,주사련뇨좌균소(STZ)제작당뇨병대서모형.조모성공후,불여강당약공제혈당,정상사양18주후,대서분별여온수、량윤통락중약、단순통락중약、단순자윤중약、단순청량중약、서사필리관위,6주후검측혈장중위동소(MOT)、담낭수축소(CCK)、생장억소(SS).결과 24주시당뇨병대서존재위장격소적문란,량윤통락방영향혈액중위장격소적분비화석방,작용파점교관,우우기탁방화서사필리.결론 량윤통락방가개선당뇨병대서위장공능장애.
Objective To study the mechanism of Liangruntongluo Recipe (Chinese medicines with functions of cooling, nourishing and dredging collaterals) and its modified formula in improving gastrointestinal function of diabete smellitus (DM) rats. Methods Male Wistar rats were used. Streptozotocin (STZ) was injected to rats to produce diabetic rat models. No Hypoglycemic drugs were administered to these rats to reduce blood glucose. After 18 weeks, warm water, Liangruntongino Recipe, Chinese medicines with function of nourishing, Chinese medicines with functions of cooling, and Cisapride were administered to the model rats. Detect the contents of plasma motilin (MOT), cholecystokinin (CCK), and somatostatin (SS) after 6 weeks. Results By affecting the secretion of gut hormone and having wide range of target, Liangrantongluo Recipe could regulate the disorder of gut hormone. The function of Liangruntongluo Recipe was better than its modified formula and cisapride.Conclusion Liangruntongluo Recipe can improve gastrointestinal dysfunction of DM rats.