国际呼吸杂志
國際呼吸雜誌
국제호흡잡지
INTERNATIONAL JOURNAL OF RESPIRATION
2012年
16期
1218-1220
,共3页
慢性阻塞性肺疾病%白介素18%肿瘤坏死因子α%白介素8%肺功能
慢性阻塞性肺疾病%白介素18%腫瘤壞死因子α%白介素8%肺功能
만성조새성폐질병%백개소18%종류배사인자α%백개소8%폐공능
Chronic obstructive pulmonary disease%Interleukin-18%Tumor necrosis factor-alpha%Interleukin-8%Lung function
目的 探讨慢性阻塞性肺疾病(COPD)患者血清白介素18(IL-18)、肿瘤坏死因子α(TNF-α)和白介素8(IL-8)的水平变化与肺功能的相关性,及其在COPD发病机制中的作用及意义.方法 采用双抗体夹心酶联免疫吸附法(ELISA),对36例COPD急性加重期患者治疗前、后血清中IL-18、TNF-α和IL-8进行检测,与12名正常健康人作比较.结果 COPD组治疗前和治疗后血清IL-18、TNF-α和IL-8水平均高于对照组(P＜0.05)；COPD组治疗前和治疗后血清IL-18、TNF-α和IL-8水平差异有统计学意义；COPD组治疗前血清IL-18、TNF-α和IL-8水平与同期肺功能呈负相关.结论 过多的IL-18、TNF-α和IL-8可能参与了COPD发病机制,细胞因子浓度的增高可能与肺功能损害程度有关.
目的 探討慢性阻塞性肺疾病(COPD)患者血清白介素18(IL-18)、腫瘤壞死因子α(TNF-α)和白介素8(IL-8)的水平變化與肺功能的相關性,及其在COPD髮病機製中的作用及意義.方法 採用雙抗體夾心酶聯免疫吸附法(ELISA),對36例COPD急性加重期患者治療前、後血清中IL-18、TNF-α和IL-8進行檢測,與12名正常健康人作比較.結果 COPD組治療前和治療後血清IL-18、TNF-α和IL-8水平均高于對照組(P＜0.05)；COPD組治療前和治療後血清IL-18、TNF-α和IL-8水平差異有統計學意義；COPD組治療前血清IL-18、TNF-α和IL-8水平與同期肺功能呈負相關.結論 過多的IL-18、TNF-α和IL-8可能參與瞭COPD髮病機製,細胞因子濃度的增高可能與肺功能損害程度有關.
목적 탐토만성조새성폐질병(COPD)환자혈청백개소18(IL-18)、종류배사인자α(TNF-α)화백개소8(IL-8)적수평변화여폐공능적상관성,급기재COPD발병궤제중적작용급의의.방법 채용쌍항체협심매련면역흡부법(ELISA),대36례COPD급성가중기환자치료전、후혈청중IL-18、TNF-α화IL-8진행검측,여12명정상건강인작비교.결과 COPD조치료전화치료후혈청IL-18、TNF-α화IL-8수평균고우대조조(P＜0.05)；COPD조치료전화치료후혈청IL-18、TNF-α화IL-8수평차이유통계학의의；COPD조치료전혈청IL-18、TNF-α화IL-8수평여동기폐공능정부상관.결론 과다적IL-18、TNF-α화IL-8가능삼여료COPD발병궤제,세포인자농도적증고가능여폐공능손해정도유관.
Objective To investigate the relationship between serum levels of interleukin-18 (IL-18),tumor necrosis factor-alpha (TNF-α),interleukin-8 ( IL-8 ) and pulmonary function in patients with chronic obstructive pulmonary disease (COPD) to evaluate their roles in the pathogenesis of COPD.Methods The serum IL-18,TNF-α and IL-8 levels of 36 COPD patients with acute exacerbation and 15 healthy people ( control ) were determined by using double-antibody sandwich enzyme-linked immunosorbent assay.Results Serum levels of IL-18,TNF-α and IL-8 in patients with acute exacerbation of COPD before treatment and after were treatment significantly higher than those in control group ( P ＜0.05).The serum IL-18,TNF-α and IL-8 levels of COPD group before the treatment were significantly higher than those after the treatment.Serum level of IL-18,TNF-α and L-8 revealed notably negative correlated with the corresponding period pulmonary function.Conclusions Overproduction of IL-18,TNF-α and IL-8 are involved in the process of inflammatory reaction of COPD.The damage of lung function in COPD patients is associated with the increase of serum cytokine level.
