化工中间体
化工中間體
화공중간체
CHEMICAL INTERMEDIATE
2010年
9期
35-37
,共3页
Wittig反应 α,β-不饱和酯 三苯基氧膦
Wittig反應 α,β-不飽和酯 三苯基氧膦
Wittig반응 α,β-불포화지 삼분기양련
Wittig reaction%α%β-unsaturated ester%triphenylphosphine oxide
本论文对Wittig反应合成α,β-不饱和酯后处理做了改进。利用副产物三苯基氧膦易结晶的特点,先用重结晶的方法除去大部分副产物三苯基氧膦后,再用柱层析色谱法纯化得到产物。该方法不但减少了硅胶和洗脱剂的用量,而且使分离效果更好,具有一定的经济和环保意义。
本論文對Wittig反應閤成α,β-不飽和酯後處理做瞭改進。利用副產物三苯基氧膦易結晶的特點,先用重結晶的方法除去大部分副產物三苯基氧膦後,再用柱層析色譜法純化得到產物。該方法不但減少瞭硅膠和洗脫劑的用量,而且使分離效果更好,具有一定的經濟和環保意義。
본논문대Wittig반응합성α,β-불포화지후처리주료개진。이용부산물삼분기양련역결정적특점,선용중결정적방법제거대부분부산물삼분기양련후,재용주층석색보법순화득도산물。해방법불단감소료규효화세탈제적용량,이차사분리효과경호,구유일정적경제화배보의의。
The present paper has made an improvement to the post-processing of Wittig reaction Synthesis ofα,β-unsaturated ester.The products were purified by column chromatography after the majority of the by-product triphenylphosphine oxide was removed by recrystallization due to its characteristic of easy-crystallization.This method diminished the use of silica gel and the eluent and made the separation more efficient.So it proved to be an economical and environmentally benign method.
