CAJ | 학술논문

目的观察雷尼酸锶(SR)对尾吊大鼠血清骨代谢指标、骨密度、骨生物力学的影响.方法选用3月龄雄性健康SD大鼠30只,随机分为5组:全程对照组(A组)、尾吊时服用SR组(B组)、尾吊后服用SR组(C组)、全程服用SR组(D组)、尾吊后对照组(E组),共8周(其中尾吊4周).分别检测血清骨代谢指标,行骨密度检查及骨生物力学实验.结果尾吊后对照组碱性磷酸酶和骨钙素活性明显高于其余各组(P＜0.05).骨密度、最大压缩载荷、最大三点弯曲载荷均比A组低,经过SR治疗后各组指标均有不同程度提高(P＜0.05),但尾吊后服用SR组和全程服用SR组效果相当且优于尾吊时服用SR组.结论雷尼酸锶对尾吊大鼠骨质疏松有防治作用.
목적 관찰뢰니산송(SR)대미조대서혈청골대사지표、골밀도、골생물역학적영향.방법 선용3월령웅성건강SD대서30지,수궤분위5조:전정대조조(A조)、미조시복용SR조(B조)、미조후복용SR조(C조)、전정복용SR조(D조)、미조후대조조(E조),공8주(기중미조4주).분별검측혈청골대사지표,행골밀도검사급골생물역학실험.결과 미조후대조조감성린산매화골개소활성명현고우기여각조(P＜0.05).골밀도、최대압축재하、최대삼점만곡재하균비A조저,경과SR치료후각조지표균유불동정도제고(P＜0.05),단미조후복용SR조화전정복용SR조효과상당차우우미조시복용SR조.결론 뢰니산송대미조대서골질소송유방치작용.
Objective To observe the effects of strontium ranelate (SR) on simulated Weightlessness male rats.Methods 30 three-month-old male SD rats were randomly divided into 5 groups:whole rang control group(group A),SR intervention when tailing suspension group(group B),SR intervention after tail suspension group(group C),SR intervention all the time group(group D)and control group after tail suspension(group E).The experiment lasted 8 weeks(tail suspension with 4 weeks).The serum Ca,P,alkaline phosphatase(ALP)and bone gla protein(BGP) were assayed.Bone mineral density(BMD)was examined by DEXA,and the maximum compress load,maximum three point bending load of femur and lumbar were tested.Results In the rats of group E,ALP and BGP were significantly higher than the rest groups (P＜0.05).BMD,maximum compress load、maximum three point bending load all lower than group A(P＜0.05).Group C and group D show the equivalent effect after treated by SR,and both of them supass group B.Conclusion There were the preventive and therapeutic effects on osteoporosis in simulated weightlessness rats by strontium ranelate.