CAJ | 학술논문

传统上,细胞死亡分为凋亡和坏死两类.而近年来越来越多的研究表明坏死性凋亡是一种不同于凋亡和坏死的新型细胞死亡途径,在多种疾病模型中发挥着重要作用.本文对坏死性凋亡的产生机制、坏死性凋亡同凋亡和坏死的区别及其在疾病和药物靶点发现中的作用进行综述,以利于加深对不同细胞死亡方式的认识并促进相关新药的研发.
전통상,세포사망분위조망화배사량류.이근년래월래월다적연구표명배사성조망시일충불동우조망화배사적신형세포사망도경,재다충질병모형중발휘착중요작용.본문대배사성조망적산생궤제、배사성조망동조망화배사적구별급기재질병화약물파점발현중적작용진행종술,이리우가심대불동세포사망방식적인식병촉진상관신약적연발.
Traditionally, cell death has been categorized into apoptosis or necrosis. However, a growing number of research indicates necroptosis, distinct from apoptosis and necrosis, contributes to a range of human diseases as a new mechanism of cell death. In order to achieve a better understanding of different cell death models and an improvement for development of new drugs associated with this pathway, the mechanism of necroptosis, the differences among apoptosis, necrosis and necroptosis, as well as the role of necroptosis in human diseases and its relation to discovery of drug targets, are discussed in this article.