CAJ | 학술논문

目的:探讨FⅦ活化蛋白酶(Factor Ⅶ-activating protease,FSAP) 基因的Marburg I 型多态性与脑梗死发病之间的相关性,并分析FSAP的Marburg I 型多态性是否为脑梗死的危险因子之一.方法:应用单链构象多态性PCR技术(SSCP-PCR),对159例临床确诊的脑梗死患者及179例年龄、性别相匹配的无血栓性疾病病史志愿者的FSAP基因进行多态性分析.结果:FSAP基因表型在病例组及对照组中均为野生型纯合子,未检测到Marburg I 型突变型.发现1例FSAP基因点突变(C1815T).结论:FSAP基因的Marburg I 型多态性与脑梗死发病可能无相关性.
목적:탐토FⅦ활화단백매(Factor Ⅶ-activating protease,FSAP) 기인적Marburg I 형다태성여뇌경사발병지간적상관성,병분석FSAP적Marburg I 형다태성시부위뇌경사적위험인자지일.방법:응용단련구상다태성PCR기술(SSCP-PCR),대159례림상학진적뇌경사환자급179례년령、성별상필배적무혈전성질병병사지원자적FSAP기인진행다태성분석.결과:FSAP기인표형재병례조급대조조중균위야생형순합자,미검측도Marburg I 형돌변형.발현1례FSAP기인점돌변(C1815T).결론:FSAP기인적Marburg I 형다태성여뇌경사발병가능무상관성.
Objective To determine the relation between Marburg I polymorphism of FactorⅦ-activating protease (FSAP) and cerebral infarction,and to analyze whether it is one of the risk factors of cerebral infarction.Methods Single strand conformation polymorphism-polymerase chain reaction (SSCP-PCR) was applied for the polymorphism analysis of FSAP in 159 patients with cerebral infarction and 179 non-cerebral infarction subjects.Results The phenotypes of FSAP in both the patients and the control subjects were wild type GG;no mutant of Marburg I was found. But a new gene mutation was tested, which had not been reported, requiring further investigation. Conclusion Marburg I polymorphism of FSAP may not be associated with cerebral infarction.