上海交通大学学报(医学版)
上海交通大學學報(醫學版)
상해교통대학학보(의학판)
JOURNAL OF SHANGHAI JIAOTONG UNIVERSITY(MEDICAL SCIENCE)
2009年
11期
1387-1390
,共4页
胃癌%白细胞介素%炎症
胃癌%白細胞介素%炎癥
위암%백세포개소%염증
gastric cancer%interleukins%inflammation
幽门螺杆菌(Helicobacter pylori,H.pylori)感染已被世界卫生组织确定为胃癌危险因素.H.pylori感染引起胃黏膜的炎症,诱导宿主产生多种细胞因子,其中有些因子可导致胃黏膜上皮细胞向癌演变.H.pylori感染后白细胞介素(ILs)表达发生明显改变,不同的ILs在胃癌的发生和发展过程中发挥不同的作用.文章就ILs在胃癌发生和发展中的作用研究进展作一综述.
幽門螺桿菌(Helicobacter pylori,H.pylori)感染已被世界衛生組織確定為胃癌危險因素.H.pylori感染引起胃黏膜的炎癥,誘導宿主產生多種細胞因子,其中有些因子可導緻胃黏膜上皮細胞嚮癌縯變.H.pylori感染後白細胞介素(ILs)錶達髮生明顯改變,不同的ILs在胃癌的髮生和髮展過程中髮揮不同的作用.文章就ILs在胃癌髮生和髮展中的作用研究進展作一綜述.
유문라간균(Helicobacter pylori,H.pylori)감염이피세계위생조직학정위위암위험인소.H.pylori감염인기위점막적염증,유도숙주산생다충세포인자,기중유사인자가도치위점막상피세포향암연변.H.pylori감염후백세포개소(ILs)표체발생명현개변,불동적ILs재위암적발생화발전과정중발휘불동적작용.문장취ILs재위암발생화발전중적작용연구진전작일종술.
Helicobacter pylori (H. Pylori) infection has been an established risk factor for gastric cancer identified by World Health Organization. H. Pylori triggers chronic inflammation of gastric mucosa and induces host cells to release various cytokines, some of which might lead normal epithelial cells to transfer to gastric cancer. Expression of interleukins in gastric mucosa experiences significant changes after H. Pylori infection. Interleukins play different roles in carcinogenesis and development of gastric cancer. This article briefly reviews the research advances of roles of interleukins in carcinogenesis and development of gastric cancer.