CAJ | 학술논문

目的探讨TRAIL和Survivin在卵巢癌组织中的表达及与临床病理因素的关系.方法用免疫组化SP 法检测10例正常卵巢、20例良性卵巢肿瘤及60例卵巢癌组织中TRAIL蛋白和Survivin蛋白表达情况,分析TRAIL和Survivin蛋白与卵巢癌临床病理因素的关系.结果 ①正常卵巢组织、良性卵巢肿瘤、卵巢癌中TRAIL蛋白的表达率分别为90.0%、80.0%、38.3%,Survivin蛋白的表达率分别为0%、20.0%、63.3%.两者间比较:在正常卵巢和良性卵巢肿瘤中TRAIL蛋白、Survivin蛋白的表达差异无显著性意义(P>0.05);而良性卵巢肿瘤和恶性卵巢肿瘤中TRAIL蛋白、Survivin蛋白的表达差异均有显著性意义(P<0.05);②在卵巢癌中TRAIL蛋白表达与组织学类型、病理分级无关(P>0.05),与临床分期期别密切相关(P<0.05);Survivin蛋白的表达与组织学类型无关(P>0.05),与病理分级、临床分期期别密切相关(P<0.05).结论 TRAIL蛋白和Survivin蛋白可能共同参与了卵巢癌的发生发展过程.并且可能通过减少TRAIL蛋白表达,升高Survivin蛋白表达,起到协同抑制肿瘤细胞凋亡作用,从而参与了卵巢肿瘤发生过程中细胞凋亡的调控.
목적 탐토TRAIL화Survivin재란소암조직중적표체급여림상병리인소적관계.방법 용면역조화SP 법검측10례정상란소、20례량성란소종류급60례란소암조직중TRAIL단백화Survivin단백표체정황,분석TRAIL화Survivin단백여란소암림상병리인소적관계.결과 ①정상란소조직、량성란소종류、란소암중TRAIL단백적표체솔분별위90.0%、80.0%、38.3%,Survivin단백적표체솔분별위0%、20.0%、63.3%.량자간비교:재정상란소화량성란소종류중TRAIL단백、Survivin단백적표체차이무현저성의의(P>0.05);이량성란소종류화악성란소종류중TRAIL단백、Survivin단백적표체차이균유현저성의의(P<0.05);②재란소암중TRAIL단백표체여조직학류형、병리분급무관(P>0.05),여림상분기기별밀절상관(P<0.05);Survivin단백적표체여조직학류형무관(P>0.05),여병리분급、림상분기기별밀절상관(P<0.05).결론 TRAIL단백화Survivin단백가능공동삼여료란소암적발생발전과정.병차가능통과감소TRAIL단백표체,승고Survivin단백표체,기도협동억제종류세포조망작용,종이삼여료란소종류발생과정중세포조망적조공.
Objective To investigate the expressions of TRAIL and Survivin proteins in ovarian carcinoma and their relationships to clinicopathologic factors. Methods The expressions of TRAIL and Survivin proteins were detected by immunohistochemical SP technique in 10 cases of normal ovaries, 20 cases of ovarian benign tumor and 60 cases of ovarian carcinoma. The relationships between TRAIL and Survivin proteins and clinicopathological factors in ovarian carcinoma were analyzed. Results ①The positive expression rate of TRAIL protein in normal ovaries , ovarian benign tumor and ovarian carcinoma was 90.0%、80.0%、38.3% respectively,that of Survivin proteins in normal ovaries, ovarian benign tumor and ovarian carcinoma was 0%、20.0%、63.3% respectively. Compare in two groups about the expression rates of TRAIL and Survivin proteins: there was no significant difference between normal ovaries and ovarian benign tumors(P>0.05), but there was statistically difference between ovarian benign tumors and ovarian carcinoma(P<0.05).②The expression of TRAIL protein in ovarian carcinoma was not correlated with histological and pathological grade, but was closely correlated with clinical stage; The expression of Survivin proteins in ovarian carcinoma was not correlated with pathological type, but was closely correlated with histological and clinical stage. Conclusion TRAIL and Survivin proteins should play important roles together in the genesis and development of ovarian carcinoma. By reducing the expression of TRAIL and elevating the expression of Survivin, there may be a coordinated effect to inhabit the apoptosis, it may promote the genesis and development of ovarian carcinoma commonly.