CAJ | 학술논문

目的探讨哮喘患者发作期及激素治疗前后引痰液中炎症介质IL-8,TNF-α和ECP(嗜酸细胞阳离子蛋白)含量对判定哮喘气道炎症及疗效的意义.方法用高渗盐水雾化引痰、荧光免疫法及酶联免疫法检测发作期哮喘患者以及吸入必可酮(二丙酸倍氯米松气雾剂)治疗4wk后引痰液中IL-8,TNF-α和ECP等水平.结果哮喘患者引痰液中IL-8,TNF-α和ECP等水平在必可酮治疗4wk后较其发作期有显著下降.结论测定引痰液炎症介质IL-8,TNF-α和ECP等水平可用于评估哮喘气道炎症及治疗效果.
목적 탐토효천환자발작기급격소치료전후인담액중염증개질IL-8,TNF-α화ECP(기산세포양리자단백)함량대판정효천기도염증급료효적의의.방법 용고삼염수무화인담、형광면역법급매련면역법검측발작기효천환자이급흡입필가동(이병산배록미송기무제)치료4wk후인담액중IL-8,TNF-α화ECP등수평.결과 효천환자인담액중IL-8,TNF-α화ECP등수평재필가동치료4wk후교기발작기유현저하강.결론 측정인담액염증개질IL-8,TNF-α화ECP등수평가용우평고효천기도염증급치료효과.
AIM To assess whether levels of IL-8, TNF-α and ECP in theinduced sputum reflect the level of the airway inflammation of bronchial asthma. METHODS Induced sputum was used by inhalation of hypertonic saline to analyse concentrations of eosinophil cationic protein (ECP), interleukin-8 (IL-8) and tumour necrosis factor-α(TNF-α) by radioimmunoassay (RIA) or enzyme linked immunosorbent assay (ELISA). RESULTS Levels of TNF-α, ECP and IL-8 in patients with inhalation of Bicotide for 4 weeks were less than those with acute attacks of asthma. CONCLUSION Analysing the induced sputum can be used to assess the airway inflammation and the effects of treatment.