CAJ | 학술논문

目的研究5种维吾尔药的清除羟自由基(.OH)及保护DNA氧化损伤的作用。方法采用现代生物化学发光分析技术，以CuSO4-VitC-H2O2-酵母菌发光体系测定药材对.OH的清除作用。结果研究表明，5种维吾尔药材对.OH具有不同程度的清除作用，并能保护DNA的氧化损伤，而且它们清除.OH及抗DNA氧化损伤的作用与它们的浓度之间存在正比性依赖关系。结论5种维吾尔药清·OH及抗DNA损伤的作用可能是它们抗衰老、防治某些疾病的主要作用机制之一。
목적연구5충유오이약적청제간자유기(.OH)급보호DNA양화손상적작용。방법채용현대생물화학발광분석기술，이CuSO4-VitC-H2O2-효모균발광체계측정약재대.OH적청제작용。결과연구표명，5충유오이약재대.OH구유불동정도적청제작용，병능보호DNA적양화손상，이차타문청제.OH급항DNA양화손상적작용여타문적농도지간존재정비성의뢰관계。결론5충유오이약청·OH급항DNA손상적작용가능시타문항쇠로、방치모사질병적주요작용궤제지일。
Object To study the hydroxyl radical scavenging and DNA damageprotecting activities of 5 Uighur herbal medicines-Euphorbi a humifusa Willd., Borago officinalis L, Cassi a angustifolia Vahl, Terminalia chebula Retz. and Fomes officinalis (Vill. ex Fr.) Bres. Methods The hydroxyl radical scavenging action and DNA damage protection action were determ ined by CuSO4-Vit C-H2O2 yeast and CuSO4-Vit C-H2O2-phen-DNA c hemiluminescence systems respectively. Results All 5 Uighur me dicinal herbs showed hydroxyl radical scavenging and DNA damage protection activ ities in dose-dependent manners. Conculsion The hydroxyl radi cal scavenging and DNA protective effects may possibly be the mechanisms of thei r antiaging and therapeutic effects against various diseases.