CAJ | 학술논문

目的为了解成人和儿童各个年龄阶段人群感染Hp后的胃粘膜病理变化特点及探索其可能的发病机制。方法对313例成人和儿童Hp相关性胃炎病人的胃粘膜病理作了回顾性分析。结果儿童Hp相关性胃炎的病理变化以浅表性炎症为主，而在成人年龄越大，萎缩性胃炎的比例越高，两者比较差异显著(X=40.3967，P<0.005)。成人组胃粘膜炎症中中性白细胞的比例明显高于儿童组。胃粘膜固有腺体萎缩和肠上皮化生也明显高于儿童组(U*=11.079，P<0.001，U**=4.2169，P<0.001)。结论各个年龄人群感染Hp后在胃粘膜的病理变化上有着密切的联系，年龄越小，病变越轻，随着年龄增大，除了炎症程度的加重外，同时还表现出胃粘膜萎缩和肠上皮化生。
목적위료해성인화인동각개년령계단인군감염Hp후적위점막병리변화특점급탐색기가능적발병궤제。방법대313례성인화인동Hp상관성위염병인적위점막병리작료회고성분석。결과인동Hp상관성위염적병리변화이천표성염증위주，이재성인년령월대，위축성위염적비례월고，량자비교차이현저(X=40.3967，P<0.005)。성인조위점막염증중중성백세포적비례명현고우인동조。위점막고유선체위축화장상피화생야명현고우인동조(U*=11.079，P<0.001，U**=4.2169，P<0.001)。결론각개년령인군감염Hp후재위점막적병리변화상유착밀절적련계，년령월소，병변월경，수착년령증대，제료염증정도적가중외，동시환표현출위점막위축화장상피화생。
Objective To study the pathologic and mechanism of changes of gastric mucosa in adult and pediatric patients after Hp infection. Methods Retrospective analysis of 313 cases of adult and pediatric Hp-associated gastritis was performed. Results Superficial inflammation was the main pathologic change in pediatric Hp-associated gastritis, but in adult, atrophic gastritis became more common, there was significant difference between the two(X =40. 3967, P < 0. 005). The proportion of neutrophilic infiltration in adult gastric mucosa was significantly higher thanthat in children, so were the intestinal metaplasia and glandular atrophy. (U * = 11. 079, P = 0. 001; U** = 4.2169, P =0.001). Conclusion Pathologic changes after Hp infection are closely related with age of the patient, with aadvancing agemore severe inflammation,mucosal atrophy and intestinal metaplasia can occur. (Shanghai Med J, 2001,24:105-107)