CAJ | 학술논문

采用大鼠心肌缺血再灌注模型观察黄芩甙对缺血再灌注后心律失常和心肌损伤的保护作用。实验大鼠分为假手术组、缺血再灌注组、黄芩甙I组、黄芩甙II组和维拉帕米组。观察对各组大鼠心电图、血清磷酸肌酸激酶（CPK）、谷胱甘肽过氧化物酶（GSH-PX）及心肌组织内超氧化物歧化酶（SOD）、脂质过氧化物丙二醛（MDA）的影响。结果表明，黄芩甙可显著减少再灌注性心律失常发生率，降低CPK活性和MDA含量，升高SOD和GSH-PX活性。提示黄芩甙对再灌注心肌具有保护作用，其机制可能与其抗脂质过氧化反应有关。
채용대서심기결혈재관주모형관찰황금대대결혈재관주후심률실상화심기손상적보호작용。실험대서분위가수술조、결혈재관주조、황금대I조、황금대II조화유랍파미조。관찰대각조대서심전도、혈청린산기산격매（CPK）、곡광감태과양화물매（GSH-PX）급심기조직내초양화물기화매（SOD）、지질과양화물병이철（MDA）적영향。결과표명，황금대가현저감소재관주성심률실상발생솔，강저CPK활성화MDA함량，승고SOD화GSH-PX활성。제시황금대대재관주심기구유보호작용，기궤제가능여기항지질과양화반응유관。
Protective effects of baicalin on myocardium ischemia-repurfusion injury were studied in rats. Wistar rats were divided into 5 groups: pseudo operation; ischemia-reperfusion operation; ischemia-reperfusion with baicalin 20 mg/kg and 80 mg/kg; ischemic-reperfusion with Verapamil 1 mg/kg. The results showed that baicalin reduced frequency of arrhythmia, contents of CK and MDA, and increased activities of SOD and GSH-PX. The results suggest that baicalin possesses protective effects on myocardium ischemia-reperfusion injury in rats and its mechanism is related to inhibition of lipid peroxidation.