CAJ | 학술논문

目的　研究用三甲基氯化锡(TMT-Cl)引发低血钾症动物模型的方法。方法　给SD大鼠腹腔注射TMT-Cl，观察其半数致死剂量(LD50)以及血钾、血钠、血氯水平与TMT-Cl的剂量和染毒时间的关系。结果　TMT-Cl的LD50为14.7 mg/kg。随着剂量的增加，血钾水平显著下降，死亡明显加快；10 mg/kg组血钾随着染毒时间增加而不断下降，至第6 d达到最低为4.85 mmol/L，第11 d开始回升，但需到28 d后才恢复至正常水平。血钾下降的速度及程度与中毒表现有关。染毒后0.5 h动物血钠水平也明显下降，但24 h后均恢复正常。结论　采用TMT-Cl可以制作大鼠低血钾症动物模型。
목적　연구용삼갑기록화석(TMT-Cl)인발저혈갑증동물모형적방법。방법　급SD대서복강주사TMT-Cl，관찰기반수치사제량(LD50)이급혈갑、혈납、혈록수평여TMT-Cl적제량화염독시간적관계。결과　TMT-Cl적LD50위14.7 mg/kg。수착제량적증가，혈갑수평현저하강，사망명현가쾌；10 mg/kg조혈갑수착염독시간증가이불단하강，지제6 d체도최저위4.85 mmol/L， 제11 d개시회승，단수도28 d후재회복지정상수평。혈갑하강적속도급정도여중독표현유관。염독후0.5 h동물혈납수평야명현하강，단24 h후균회복정상。결론　채용TMT-Cl가이제작대서저혈갑증동물모형。
Objective　To study the methods in establishing hypokalemia animal model by trimethyltin chloride (TMT-Cl).Methods　SD rats were treated with TMT-Cl (ip). The main measurements include the LD50, plasma K＋，Na+,Cl- levels, the dose effect and trime effect of TMT-Cl.Results　The LD50 of TMT-Cl (ip) was 14.7 mg/kg. With the increasing of the dosage, the plasma K＋ level dropped rapidly and then, the death outcome was caused by quickly. In the low dosage group (10 mg/kg), the plasma K＋ level dropped slowly. The lowest plasma K＋ level (4.85 mmol/L) was detected in day 6. The plasma K＋ level raised again in day 11, and restored in day 28. It was obvious that poison symptoms were corresponded with the speed and the span of K＋ level decline. The plasma Na＋ level also dropped at 0.5 h after TMT-Cl treatment, but it recovered 24 h later. Conclusion　Trimethyltin chloride could establish hypokalemia model in SD rats.