CAJ | 학술논문

目的：评价樟脑油精喷剂的药效及其在使用中的安全性。方法：将樟脑油精涂于裸露皮肤上，进行驱蚊试验；取白色念球菌（ATCC10231）悬液加入樟脑油精，观察对真菌的抑制作用；急性经口毒性试验采用一次性灌胃给药；急性皮肤刺激和眼刺激试验直接涂药于家兔皮肤和滴药于眼结膜囊内。结果：驱蚊保护时间达6h以上；抑菌率达99.99%;小鼠急性经口LD50为1 302.25mg/kg；对家兔皮肤刺激积分值为0，48h后对眼刺激平均指数为0.5。结论：本品对蚊虫有一定驱避保护作用，对霉菌生长有较强的抑制作用，而且毒性低，使用安全。
목적：평개장뇌 유정분제적약효급기재사 용중적안전성。방법：장장뇌유정도우라로피부상，진행구문시험 ；취백색념구균（ATCC10231）현액가입장뇌유정，관찰대진균적 억제작용；급성경구독성시험채용일차성관위급약；급성피부자격화안자격시험직접도약우 가토피부화적약우안결막낭내。결과：구문보호시간체6h이상；억 균솔체99.99%;소서 급성경구LD50위1 302.25mg/kg；대가토피부자격적분치위0，48h후대안자격평 균지수위0.5。결론：본품대문충유일정구피보호작용，대매균 생장유교강적억제작용，이차독성저，사용안전。
Objective:To evaluate repellent efficacy,fun gistatic efficacy and saf ety of the camphor oil spray.Method:Place the human volunt eer's hand treated with the camphor oil inside a cage containing 300 Aedes alb opictus,for 2 min, and observe the treated skin surface for mosquit oes which landed and attempted to feed. Mingle the camphor oil and the fungous s uspension,Candida albicans,culture and count the number of mold.Infuse the m ice with the spray by single oral injection,and treat directly the rabbits' expo sed skin and the conjunc tiva crypt with the spray.Result:The repellent protection time against Aedes albopictus was over 6h. Mean fungistatic rate to mold was 99.99%. The acute oral LD50 was 1 302.5mg/kg in mice. This produc t was non-irritant to skin,but slightly irritant to eye. Conclusion: The camphor oil spray is a better repellency against mosquito,inhibit or against mold,and low acute toxicity substance.