CAJ | 학술논문

目的旨在研究过氧化物酶增殖物活化受体γ2(PPARγ2)基因Pro12Ala多态性与2型糖尿病相关性.方法选取北京地区汉族101对病例-对照配偶对,应用聚合酶链反应-长度多态性方法进行基因型测定.结果对照组中携带Ala12等位基因组,血清载脂蛋白B明显低于Pro12Pfo基因型组(P=0.006);但Pro12Ala多态性与2型糖尿病不相关(OR=1.48,95%CI=0.52～4.18,P=0.461).结论在北京汉族人群中,PPARγ2基因Pro12Ala多态性与脂肪代谢异常有关,PPARγ2基因多态性可能不是2型糖尿病主要的致病因素.
목적지재연구과양화물매증식물활화수체γ2(PPARγ2)기인Pro12Ala다태성여2형당뇨병상관성.방법선취북경지구한족101대병례-대조배우대,응용취합매련반응-장도다태성방법진행기인형측정.결과대조조중휴대Ala12등위기인조,혈청재지단백B명현저우Pro12Pfo기인형조(P=0.006);단Pro12Ala다태성여2형당뇨병불상관(OR=1.48,95%CI=0.52～4.18,P=0.461).결론재북경한족인군중,PPARγ2기인Pro12Ala다태성여지방대사이상유관,PPARγ2기인다태성가능불시2형당뇨병주요적치병인소.
Objective To study the association of peroxisome proliferator activated receptorγ2 (PPARγ2) gene polymorphism with type 2 diabetes mellitus.Methods PPARγ2 gene Pro12Ala polymorphism was examined using polymerase chain reaction and restriction fragment length polymorphism (PCR RFLP) in 101 couples of type 2 diabetes mellitus normal control.Results In control group, heterozygosity carriers had lower serum apolipoprotein B (P=0 006).The Pro12Ala polymorphism in PPARγ2 gene is not associated with type 2 diabetes mellitus(OR=1.48,95%CI=0.52～4.18,P=0.461).Conclusion PPARγ2 gene Pro12Ala polymorphism is associated with abnormal lipid metabolism; PPARγ2 gene may not play a critical role in the development of type 2 diabetes mellitus in Han of Beijing Chinese.