CAJ | 학술논문

目的：探讨P27、P53和增殖细胞核抗原（PCNA）在胃癌组织中的表达及其与临床病理指标及预后的相关性。方法：应用免疫组织化学SP法，检测62例人胃癌组织中P27、P53、PCNA的表达。结果：胃癌组织中，P27、P53、PCNA表达的阳性率分别为37.1％、40.4%、83.9%。P27的表达与Bormann分型、肿瘤浸润深度、淋巴结及远处转移、临床分期有关；P53表达与患者性别、远处转移、临床分期有关；而PCNA仅与患者年龄、肿瘤分化程度有关。P27阳性组5年生存率高于阴性组，P27与PCNA表达呈显著负相关。结论：胃癌组织中P27、P53、PCNA的表达可作为判断肿瘤恶性程度、有无转移及预后的重要参考指标。
목적：탐토P27、P53화증식세포핵항원（PCNA）재위암조직중적표체급기여림상병리지표급예후적상관성。방법：응용면역조직화학SP법，검측62례인위암조직중P27、P53、PCNA적표체。결과：위암조직중，P27、P53、PCNA표체적양성솔분별위37.1％、40.4%、83.9%。P27적표체여Bormann분형、종류침윤심도、림파결급원처전이、림상분기유관；P53표체여환자성별、원처전이、림상분기유관；이PCNA부여환자년령、종류분화정도유관。P27양성조5년생존솔고우음성조，P27여PCNA표체정현저부상관。결론：위암조직중P27、P53、PCNA적표체가작위판단종류악성정도、유무전이급예후적중요삼고지표。
Objective: To investigate the relationship between P27，P53 and PCNA expression in human gastric carcinoma tissues and clinicopathological parameters. Methods: The expression of P27，P53 and PCNA in 62 human gastric carcinoma tissues was examined with immunohistochemistry SP method. Results: Positive rates of P27，P53 and PCNA expression were 37.1％, 40.4%，83.9％. P27 expression was related with Bormann type, infiltrative depth, lymph node and distant metastasis and clinical stage. P53 expression was related with sex of patients, distant metastasis and clinical stage. PCNA expression was related with age of patients and infiltrative depth of tumor. P27 positive expression group was higher than negative group as to 5-year survival. P27 expression was in reverse relation with PCNA expression. Conclusion: The expression of P27, P53 and PCNA may be regarded as an important marker in judging malignant degree of gastric carcinoma,distant metastasis and prognosis.