CAJ | 학술논문

研制了一种新型的过氧化聚吡咯膜修饰电极(OPPy/CME)作为液相色谱电化学检测器，该电极可以用来检测生物体内的单胺类神经递质及其代谢产物。用药物建立了帕金森动物试验模型，对不同情况下的试验动物脑内单胺类神经递质及其代谢产物通过微渗析取样和液相色谱电化学检测联用技术进行了测定。初步探讨了试验动物产生帕金森病的机理，为研制和筛选更有效的治疗帕金森病的新药提供了一种准确、可靠的分析手段。
연제료일충신형적과양화취필각막수식전겁(OPPy/CME)작위액상색보전화학검측기，해전겁가이용래검측생물체내적단알류신경체질급기대사산물。용약물건립료파금삼동물시험모형，대불동정황하적시험동물뇌내단알류신경체질급기대사산물통과미삼석취양화액상색보전화학검측련용기술진행료측정。초보탐토료시험동물산생파금삼병적궤리，위연제화사선경유효적치료파금삼병적신약제공료일충준학、가고적분석수단。
A novel polymer- overoxidized polypyrrole film chemically modified electrode (CME) as the liquid chromatography-electrochemical detector (LC-ECD) was fabricated and applicated, which could be used to determine the monoamine neurotransmitters. The experimental model of parkinsonian animal was established by using medicine. Microdialysis sampling coupled with LC-ECD was used to monitor the monoamine neurotransmitters and their metabolites in experimental animal brain in vivo under different situations. The mechanism of experimental animal's Parkinsonian disease was studied elementarily. An accurate and reliable analysis method was supplied for filting the new and the more effective medicine to cure parkinsonian disease.