CAJ | 학술논문

本研究比较了一种5-甲基取代的氟喹诺酮格帕沙星与氧氟沙星的体外抗生素后效应.应用光密度法测定抗生素后效应.格帕沙星与氧氟沙星对大肠埃希菌、粪肠球菌、铜绿假单胞菌和金黄色葡萄球菌均显示了较长的抗生素后效应,其中格帕沙星对金黄色葡萄球菌的抗生素后效应长于氧氟沙星.本结果对于设计临床给药方案具有一定的指导意义.
본연구비교료일충5-갑기취대적불규낙동격파사성여양불사성적체외항생소후효응.응용광밀도법측정항생소후효응.격파사성여양불사성대대장애희균、분장구균、동록가단포균화금황색포도구균균현시료교장적항생소후효응,기중격파사성대금황색포도구균적항생소후효응장우양불사성.본결과대우설계림상급약방안구유일정적지도의의.
The postantibiotic effect (PAE) of grepafloxacin, a new 5-methyl-substituted fluroquinolone, was compared with that of ofloxacin. The duration of PAE was determined by the optical density method. Grepafloxacin and ofloxacin showed significant PAEs against E. coli, E. faecalis, Ps. aeruginosa and S. aureus. The PAE of grepafloxacin against S. aureus is longer than that of ofloxacin. The results are useful for antimicrobial dosing regimens.