中国全科医学
中國全科醫學
중국전과의학
CHINESE GENERAL PRACTICE
2010年
2期
150-152
,共3页
滕海麟%吴福根%杨晓卫%林峰%李桦%周仁芳
滕海麟%吳福根%楊曉衛%林峰%李樺%週仁芳
등해린%오복근%양효위%림봉%리화%주인방
紫癜%过敏性%一氧化氮%血管内皮生长因子
紫癜%過敏性%一氧化氮%血管內皮生長因子
자전%과민성%일양화담%혈관내피생장인자
Purpura%schoenlein-henoch%Nitric oxide%Vascular endothelial growth factor
目的 探讨过敏性紫癜(HSP)患儿血清中血管内皮生长因子(VEGF)及一氧化氮(NO)的变化及其临床意义.方法 采用酶联免疫吸附法(ELISA)、硝酸酶还原法检测38例HSP患儿急性期、恢复期及24例正常健康儿(对照组)血清中VEGF及NO活性水平.结果 对照组、HSP急性期组、恢复期组儿童血清VEGF与NO水平分别为(129.4±39.1)ng/L与(80.5±15.7)μmol/L、(429.0±109.2)ng/L与(124.9±22.8)μmol/L、(252.3±63.8)ng/L与(78.0±12.4) μmol/L,3组VEGF、NO水平间差异均有统计学意义 (P<0.01).伴或不伴早期肾损害的HSP患儿血清VEGF与NO水平分别为(497.5±112.5)ng/L与(160.4±27.7)μmol/L、(393.4±95.6)ng/L与(106.5±21.1)μmol/L,2组VEGF、NO水平间差异有统计学意义 (P<0.01).HSP急性期血清VEGF与NO水平间呈直线正相关(r=0.653,P<0.01).结论 VEGF与NO在过敏性紫癜、紫癜性肾炎(HSPN)的发生、发展中发挥一定作用.监测HSP患儿血清VEGF及NO水平对判定其病情、病程、预后和指导治疗均有一定意义.
目的 探討過敏性紫癜(HSP)患兒血清中血管內皮生長因子(VEGF)及一氧化氮(NO)的變化及其臨床意義.方法 採用酶聯免疫吸附法(ELISA)、硝痠酶還原法檢測38例HSP患兒急性期、恢複期及24例正常健康兒(對照組)血清中VEGF及NO活性水平.結果 對照組、HSP急性期組、恢複期組兒童血清VEGF與NO水平分彆為(129.4±39.1)ng/L與(80.5±15.7)μmol/L、(429.0±109.2)ng/L與(124.9±22.8)μmol/L、(252.3±63.8)ng/L與(78.0±12.4) μmol/L,3組VEGF、NO水平間差異均有統計學意義 (P<0.01).伴或不伴早期腎損害的HSP患兒血清VEGF與NO水平分彆為(497.5±112.5)ng/L與(160.4±27.7)μmol/L、(393.4±95.6)ng/L與(106.5±21.1)μmol/L,2組VEGF、NO水平間差異有統計學意義 (P<0.01).HSP急性期血清VEGF與NO水平間呈直線正相關(r=0.653,P<0.01).結論 VEGF與NO在過敏性紫癜、紫癜性腎炎(HSPN)的髮生、髮展中髮揮一定作用.鑑測HSP患兒血清VEGF及NO水平對判定其病情、病程、預後和指導治療均有一定意義.
목적 탐토과민성자전(HSP)환인혈청중혈관내피생장인자(VEGF)급일양화담(NO)적변화급기림상의의.방법 채용매련면역흡부법(ELISA)、초산매환원법검측38례HSP환인급성기、회복기급24례정상건강인(대조조)혈청중VEGF급NO활성수평.결과 대조조、HSP급성기조、회복기조인동혈청VEGF여NO수평분별위(129.4±39.1)ng/L여(80.5±15.7)μmol/L、(429.0±109.2)ng/L여(124.9±22.8)μmol/L、(252.3±63.8)ng/L여(78.0±12.4) μmol/L,3조VEGF、NO수평간차이균유통계학의의 (P<0.01).반혹불반조기신손해적HSP환인혈청VEGF여NO수평분별위(497.5±112.5)ng/L여(160.4±27.7)μmol/L、(393.4±95.6)ng/L여(106.5±21.1)μmol/L,2조VEGF、NO수평간차이유통계학의의 (P<0.01).HSP급성기혈청VEGF여NO수평간정직선정상관(r=0.653,P<0.01).결론 VEGF여NO재과민성자전、자전성신염(HSPN)적발생、발전중발휘일정작용.감측HSP환인혈청VEGF급NO수평대판정기병정、병정、예후화지도치료균유일정의의.
Objective To investigate the changes of vascular endothelial growth factor (VEGF) and nitric oxide (NO) in Henoch-Schonlein Purpura(HSP).Methods Plasma levels of VEGF,NO were detected by enzyme-linked immunosorbent assay(ELISA) and nitric acid reductase in 38 HSP inpatients in acute or recovery phase and 24 normal children.Results The levels of VEGF,NO of groups control,acute phase,recovery were 129.4±39.1 ng/L and 80.5±15.7μmol/L,429.0±109.2 ng/L and 124.9±22.8 μmol/L,252.3±63.8 ng/L and 78.0±12.4 μmol/L,respectively,the difference was significant (P＜0.01).The levels of VEGF,NO of patients with early renal damage or without were 497.5±112.5 ng/L and 160.4±27.7 μmol/L,393.4±95.6 ng/L and 106.5±21.1 μmol/L,respectively,the difference was significant (P＜0.01).There was a positive linear correlation between serum VEGF and NO(r=0.653,P＜0.01).Conclusion VEGF and NO may play a certain role in the occurrence and development of HSP and HSPN.Monitoring of serum levels of VEGF,NO is of some significance in determining HSP severity,courses,prognoses and guiding treatment.
