中国激光医学杂志
中國激光醫學雜誌
중국격광의학잡지
980235.htm
2010年
1期
13-16
,共4页
尹锐%郝飞%邓军%邹永珍%顾洪芝
尹銳%郝飛%鄧軍%鄒永珍%顧洪芝
윤예%학비%산군%추영진%고홍지
尖锐湿疣%氨基酮戊酸%光动力疗法
尖銳濕疣%氨基酮戊痠%光動力療法
첨예습우%안기동무산%광동력요법
Condyloma acuminatum%Aminolevulinic acid%Photodynamic therapy
目的 探讨高频电刀联合5-氨基酮戊酸(ALA)-光动力疗法治疗复发性肛周尖锐湿疣的疗效以及优化疗效对策.方法 肛周尖锐湿疣患者234例,随机分为3组,每组78例.第一组为高频电刀治疗组,以高频电刀烧灼疣体.第二组为光动力疗法治疗组,皮损区涂以20%ALA乳膏后4 h,以He-Ne激光照射,距离5～10 cm,照射时间20 min,光斑直径1～4 cm,能量密度100～130 J/cm~2.间隔7～10 d治疗1次,共治疗3次.第三组为高频电刀联合光动力疗法治疗组,高频电刀祛除疣体后立即行光动力疗法治疗.末次治疗后第1周进行疗效评价,在治疗后3个月内对患者进行随访以评价复发率.结果 3组患者治疗后疣体均完全消失,黏膜恢复正常.第一组复发率为55.1%,平均复发时间为24.6 d;第二组复发率为11.5%,平均复发天数为56.7 d;第三组复发率为9.0%,平均复发天数为80.1 d.结论 5-ALA-光动力疗法能有效治疗肛周尖锐湿疣,联合高频电刀治疗,能有效减少复发,延长复发时间.
目的 探討高頻電刀聯閤5-氨基酮戊痠(ALA)-光動力療法治療複髮性肛週尖銳濕疣的療效以及優化療效對策.方法 肛週尖銳濕疣患者234例,隨機分為3組,每組78例.第一組為高頻電刀治療組,以高頻電刀燒灼疣體.第二組為光動力療法治療組,皮損區塗以20%ALA乳膏後4 h,以He-Ne激光照射,距離5～10 cm,照射時間20 min,光斑直徑1～4 cm,能量密度100～130 J/cm~2.間隔7～10 d治療1次,共治療3次.第三組為高頻電刀聯閤光動力療法治療組,高頻電刀祛除疣體後立即行光動力療法治療.末次治療後第1週進行療效評價,在治療後3箇月內對患者進行隨訪以評價複髮率.結果 3組患者治療後疣體均完全消失,黏膜恢複正常.第一組複髮率為55.1%,平均複髮時間為24.6 d;第二組複髮率為11.5%,平均複髮天數為56.7 d;第三組複髮率為9.0%,平均複髮天數為80.1 d.結論 5-ALA-光動力療法能有效治療肛週尖銳濕疣,聯閤高頻電刀治療,能有效減少複髮,延長複髮時間.
목적 탐토고빈전도연합5-안기동무산(ALA)-광동력요법치료복발성항주첨예습우적료효이급우화료효대책.방법 항주첨예습우환자234례,수궤분위3조,매조78례.제일조위고빈전도치료조,이고빈전도소작우체.제이조위광동력요법치료조,피손구도이20%ALA유고후4 h,이He-Ne격광조사,거리5～10 cm,조사시간20 min,광반직경1～4 cm,능량밀도100～130 J/cm~2.간격7～10 d치료1차,공치료3차.제삼조위고빈전도연합광동력요법치료조,고빈전도거제우체후립즉행광동력요법치료.말차치료후제1주진행료효평개,재치료후3개월내대환자진행수방이평개복발솔.결과 3조환자치료후우체균완전소실,점막회복정상.제일조복발솔위55.1%,평균복발시간위24.6 d;제이조복발솔위11.5%,평균복발천수위56.7 d;제삼조복발솔위9.0%,평균복발천수위80.1 d.결론 5-ALA-광동력요법능유효치료항주첨예습우,연합고빈전도치료,능유효감소복발,연장복발시간.
Objective To evaluate the efficacy of topical 5-aminolevulinic acid photodynamic therapy for perianal condyloma acuminatum. Methods Totally 234 patients with perianal condyloma acuminatum were randomly assigned to the electrosurgical generator group, photodynamic therapy group, or electrosurgical generator-photodynamic therapy group. The treatment was repeated weekly for 3 times. The primary efficacy endpoint was the warts clearance rate 1 week after the last treatment. The recurrence rate was evaluated for contin-uous 3 months. Results The warts were all disappeared after treatment by three methods, respectively. The mucous membranes were all normal. The recurrence rate of the 78 patients solely treated by electresurgical generator was 55. 1% and their average recurrence intervals were 24.6 days. The recurrence rate of ALA-PDT was 11.5% and their average recurrence intervals were 56.8 days. The recurrence rate of electrosurgical generator combined with ALA-photodyrnamic therapy was 8.97% and their average recurrence intervals were 80.1 days. Conclusions The results confirm that topical 5-aminolevulinic acid photodynamic therapy is a very effective method for the treatment of perianal condyloma acuminatum, especially combined with electrosurgical generator. It can reduce the recurrence risk and prolong the recurrent time. It can improve patients qualities and cut off/decrease the scurees of infectian.
