CAJ | 학술논문

液相芯片技术是以不同荧光编码微球作为生物探针的载体,在悬浮液态体系中进行生物分子间的反应,以流式细胞术作为光学检测手段的生物芯片技术.介绍了液相芯片在自身免疫病诊断、细胞因子、传染性疾病、内分泌疾病、神经系统疾病及肿瘤标志物的检测等生物医学领域内的应用,最后对液相芯片的应用前景进行了展望.液相芯片技术由于具有高灵敏度、高速度、高通量、多指标、高准确性和良好的重复性等特点,作为生物医学先进的操作技术平台,必将有着更广阔的应用前景.
액상심편기술시이불동형광편마미구작위생물탐침적재체,재현부액태체계중진행생물분자간적반응,이류식세포술작위광학검측수단적생물심편기술.개소료액상심편재자신면역병진단、세포인자、전염성질병、내분비질병、신경계통질병급종류표지물적검측등생물의학영역내적응용,최후대액상심편적응용전경진행료전망.액상심편기술유우구유고령민도、고속도、고통량、다지표、고준학성화량호적중복성등특점,작위생물의학선진적조작기술평태,필장유착경엄활적응용전경.
Liquichip technology utilizes different fluorescent coding microbead as carriers of bio-probes and flow cytometry as optical detection method,to accomplish bio-molecules reaction in suspension liquid system.This article introduces the application of liquidchip technology in the analysis of autoimmune disease,cytokine,contagious disease,endocrinopathy,neural disease,tumor marker detection and so on.With the advantages of high sensitivity,high speed,high flux,multi-analyte,high accuracy and excellent repeatability,liquichip technology has promising prospect to be widely used as advanced biomedical detection platform.