中华放射医学与防护杂志
中華放射醫學與防護雜誌
중화방사의학여방호잡지
Chinese Journal of Radiological Medicine and Protection
2011年
6期
671-674
,共4页
于静萍%孙志强%倪新初%王坚%李毅%胡莉钧%李栋庆%孙苏平
于靜萍%孫誌彊%倪新初%王堅%李毅%鬍莉鈞%李棟慶%孫囌平
우정평%손지강%예신초%왕견%리의%호리균%리동경%손소평
食管癌%放疗%血管内皮生长因子
食管癌%放療%血管內皮生長因子
식관암%방료%혈관내피생장인자
Esophageal carcinoma%Radiotherapy%Vascular endothelial growth factor
目的 检测食管癌患者放疗前、中、后血清血管内皮生长因子(VEGF)的水平,探讨其变化及临床意义.方法 采集67例食管癌患者和30例健康体检者(健康对照组)血清,应用酶联免疫吸附法(ELISA)测定VEGF水平,并对其变化与临床分期和患者放疗疗效的关系进行分析.结果 食管癌患者放疗前、中、后血清VEGF水平均较健康对照组升高,差异有统计学意义(F=11.65,P＜0.01)；放疗后较放疗前VEGF水平明显降低,差异有统计学意义(F=10.72,P＜0.01).T3、T4患者的平均VEGF水平与健康对照组比较显著升高,差异有统计学意义(F=14.10,P＜0.01).N1、N2组患者的平均VEGF水平显著高于健康对照组,差异具有统计学意义(F=8.64,P＜0.01).可评价疗效的62例患者中,有21例放疗后血清VEGF水平较放疗前升高,有41例较放疗前降低,升高组的放疗有效率为61.90％,降低组的放疗有效率为90.24％,两组比较差异有统计学意义(x2=6.08,P＜0.05).50例CR+ PR患者放疗后及放疗中的血清VEGF水平均比放疗前显著降低,差异有统计学意义(F=7.98,P＜0.01).结论 监测食管癌患者血清VEGF水平变化可判断患者放射治疗的敏感性,对临床预测放射治疗的预后有重要的意义.
目的 檢測食管癌患者放療前、中、後血清血管內皮生長因子(VEGF)的水平,探討其變化及臨床意義.方法 採集67例食管癌患者和30例健康體檢者(健康對照組)血清,應用酶聯免疫吸附法(ELISA)測定VEGF水平,併對其變化與臨床分期和患者放療療效的關繫進行分析.結果 食管癌患者放療前、中、後血清VEGF水平均較健康對照組升高,差異有統計學意義(F=11.65,P＜0.01)；放療後較放療前VEGF水平明顯降低,差異有統計學意義(F=10.72,P＜0.01).T3、T4患者的平均VEGF水平與健康對照組比較顯著升高,差異有統計學意義(F=14.10,P＜0.01).N1、N2組患者的平均VEGF水平顯著高于健康對照組,差異具有統計學意義(F=8.64,P＜0.01).可評價療效的62例患者中,有21例放療後血清VEGF水平較放療前升高,有41例較放療前降低,升高組的放療有效率為61.90％,降低組的放療有效率為90.24％,兩組比較差異有統計學意義(x2=6.08,P＜0.05).50例CR+ PR患者放療後及放療中的血清VEGF水平均比放療前顯著降低,差異有統計學意義(F=7.98,P＜0.01).結論 鑑測食管癌患者血清VEGF水平變化可判斷患者放射治療的敏感性,對臨床預測放射治療的預後有重要的意義.
목적 검측식관암환자방료전、중、후혈청혈관내피생장인자(VEGF)적수평,탐토기변화급림상의의.방법 채집67례식관암환자화30례건강체검자(건강대조조)혈청,응용매련면역흡부법(ELISA)측정VEGF수평,병대기변화여림상분기화환자방료료효적관계진행분석.결과 식관암환자방료전、중、후혈청VEGF수평균교건강대조조승고,차이유통계학의의(F=11.65,P＜0.01)；방료후교방료전VEGF수평명현강저,차이유통계학의의(F=10.72,P＜0.01).T3、T4환자적평균VEGF수평여건강대조조비교현저승고,차이유통계학의의(F=14.10,P＜0.01).N1、N2조환자적평균VEGF수평현저고우건강대조조,차이구유통계학의의(F=8.64,P＜0.01).가평개료효적62례환자중,유21례방료후혈청VEGF수평교방료전승고,유41례교방료전강저,승고조적방료유효솔위61.90％,강저조적방료유효솔위90.24％,량조비교차이유통계학의의(x2=6.08,P＜0.05).50례CR+ PR환자방료후급방료중적혈청VEGF수평균비방료전현저강저,차이유통계학의의(F=7.98,P＜0.01).결론 감측식관암환자혈청VEGF수평변화가판단환자방사치료적민감성,대림상예측방사치료적예후유중요적의의.
Objective To investigate the changes and clinical value of serum vascular endothelial growth factor (VEGF) level before,during and after radiotherapy in patients with esophageal carcinoma.Methods The sera of 67 esophageal carcinoma patients and 30 healthy control cases were collected.The VEGF level in serum samples were measured with enzyme-linked immunosorbent assay (ELISA) method.The relations among VEGF level changes,clinical stages and radiotherapy effect were analyzed.Results The VEGF levels of patients with esophagus cancer before,during and after radiotherapy were significantly higher than those in control group ( F =11.65,P ＜ 0.01 ).The VEGF level after radiotherapy was significant lower than that before radiotherapy ( F =10.72,P ＜ 0.01 ).The average VEGF level of patients with T3 and T4 was significantly higher than that of control group ( F =14.10,P ＜ 0.01 ).The average VEGF level of patients with N1 and N2 was significantly higher than that of control group( F =8.64,P ＜0.01).In 62 patients,the serum VEGF level increased in 21 cases but decreased in 41 cases after radiotherapy.With difference in radiotherapy efficiency of 61.90％ and 90.24％,respectively(x2 =6.08,P＜ 0.05).The average VEGF level during and after radiotherapy for 50 cases of CR + PR were significantly lower than that before radiotherapy( F =7.98,P ＜ 0.01 ).Conclusions Monitoring the serum VEGF level of patients with esophagus cancer can help evaluate the radiosensitivity,which has a significance in predicting the prognosis of radiotherapy.
