中华老年医学杂志
中華老年醫學雜誌
중화노년의학잡지
Chinese Journal of Geriatrics
2008年
6期
439-441
,共3页
王荣江%邵四海%石麒麟%赵红星%郑银元%李辉%陈晓农
王榮江%邵四海%石麒麟%趙紅星%鄭銀元%李輝%陳曉農
왕영강%소사해%석기린%조홍성%정은원%리휘%진효농
膀胱肿瘤%栓塞,治疗性%新生血管化,病理性
膀胱腫瘤%栓塞,治療性%新生血管化,病理性
방광종류%전새,치료성%신생혈관화,병이성
Urinary bladder neoplasms%Embolization,therapeutic%Neovascularization,Pathologic
目的 探讨膀胱动脉化疗栓塞对膀胱癌肿瘤微血管密度变化的影响.方法 对30例膀胱癌患者化疗栓塞前、后的肿瘤组织,应用免疫组织化学SP法染色测定微血管密度,并对化疗后膀胱癌组织进行病理观察及3年生存率随访.结果 化疗栓塞前后,微血管密度值分别为69.8±3.4、56.4±3.3,差异有统计学意义(P<0.05).病理结果显示,化疗栓塞后的癌细胞有明显受损改变,患者经随访12～36个月(平均24.6个月),复发率为16.7%(5例).结论 化疗栓塞可减少膀胱癌组织微血管密度计数,提示化疗栓塞可能调节膀胱癌的分化程度,使肿瘤降级、降期,减少术后转移,降低复发率,提高生存率.
目的 探討膀胱動脈化療栓塞對膀胱癌腫瘤微血管密度變化的影響.方法 對30例膀胱癌患者化療栓塞前、後的腫瘤組織,應用免疫組織化學SP法染色測定微血管密度,併對化療後膀胱癌組織進行病理觀察及3年生存率隨訪.結果 化療栓塞前後,微血管密度值分彆為69.8±3.4、56.4±3.3,差異有統計學意義(P<0.05).病理結果顯示,化療栓塞後的癌細胞有明顯受損改變,患者經隨訪12～36箇月(平均24.6箇月),複髮率為16.7%(5例).結論 化療栓塞可減少膀胱癌組織微血管密度計數,提示化療栓塞可能調節膀胱癌的分化程度,使腫瘤降級、降期,減少術後轉移,降低複髮率,提高生存率.
목적 탐토방광동맥화료전새대방광암종류미혈관밀도변화적영향.방법 대30례방광암환자화료전새전、후적종류조직,응용면역조직화학SP법염색측정미혈관밀도,병대화료후방광암조직진행병리관찰급3년생존솔수방.결과 화료전새전후,미혈관밀도치분별위69.8±3.4、56.4±3.3,차이유통계학의의(P<0.05).병리결과현시,화료전새후적암세포유명현수손개변,환자경수방12～36개월(평균24.6개월),복발솔위16.7%(5례).결론 화료전새가감소방광암조직미혈관밀도계수,제시화료전새가능조절방광암적분화정도,사종류강급、강기,감소술후전이,강저복발솔,제고생존솔.
Objective To investigate the effect of transcatheter bladder arterial chemoembolization on microvessel density(MVD)change in bladder cancer. Methods The MVD count of bladder cancer tissue of 30 patients before and after chemoembolization were examined by SP immunohistochemical staining.Cancer tissues were examined pathology after chemoembolization.All the cases were followed up for 12 to 36 months(mean 24.6 months),the 3 years survival rate was evaluated clinically. Results MVD counts were 69.8±3.4 and 56.4±3.3 before and after therapy respectively(P<0.05).Cancer tissues were severely damaged ultramicroscopically after interventional chemotherapy.The recurrent rate was 16.67%in 30 cases. Conclusions The chemoembolization could decrease MVD,improve survival rate and reduce the recurrence rate.
