国际医药卫生导报
國際醫藥衛生導報
국제의약위생도보
INTERNATIONAL MEDICINE & HEALTH GUIDANCE NEWS
2012年
19期
2873-2875
,共3页
来氟米特%环磷酰胺%肾病综合征
來氟米特%環燐酰胺%腎病綜閤徵
래불미특%배린선알%신병종합정
Leflunomide%Cyclophosphamide%Nephrotic syndrome
目的 探究难治性肾病综合征的最佳治疗方法.方法 将我院收治的难治性肾病综合征病人70例,分为实验组与对照组,实验组在激素治疗的基础上加用来氟米特,对照组在激素治疗的基础上加用环磷酰胺.观察比较实验组与对照组患者的生化指标改变情况和临床疗效.结果 实验组与对照组用药后胆固醇、三酰甘油水平和24h尿蛋白定量都显著下降,白蛋白水平明显升高(P＜ 0.05)；两组之间相比,实验组白蛋白水平和24h尿蛋白定量变化更显著(P＜0.05).实验组总有效率为82.9％,对照组总有效率为74.3％(P＞0.05).结论 难治性肾病综合征的最佳治疗方法:来氟米特联合糖皮质激素,该方法生化指标改善显著,有效率高,在临床上应首选此方法.
目的 探究難治性腎病綜閤徵的最佳治療方法.方法 將我院收治的難治性腎病綜閤徵病人70例,分為實驗組與對照組,實驗組在激素治療的基礎上加用來氟米特,對照組在激素治療的基礎上加用環燐酰胺.觀察比較實驗組與對照組患者的生化指標改變情況和臨床療效.結果 實驗組與對照組用藥後膽固醇、三酰甘油水平和24h尿蛋白定量都顯著下降,白蛋白水平明顯升高(P＜ 0.05)；兩組之間相比,實驗組白蛋白水平和24h尿蛋白定量變化更顯著(P＜0.05).實驗組總有效率為82.9％,對照組總有效率為74.3％(P＞0.05).結論 難治性腎病綜閤徵的最佳治療方法:來氟米特聯閤糖皮質激素,該方法生化指標改善顯著,有效率高,在臨床上應首選此方法.
목적 탐구난치성신병종합정적최가치료방법.방법 장아원수치적난치성신병종합정병인70례,분위실험조여대조조,실험조재격소치료적기출상가용래불미특,대조조재격소치료적기출상가용배린선알.관찰비교실험조여대조조환자적생화지표개변정황화림상료효.결과 실험조여대조조용약후담고순、삼선감유수평화24h뇨단백정량도현저하강,백단백수평명현승고(P＜ 0.05)；량조지간상비,실험조백단백수평화24h뇨단백정량변화경현저(P＜0.05).실험조총유효솔위82.9％,대조조총유효솔위74.3％(P＞0.05).결론 난치성신병종합정적최가치료방법:래불미특연합당피질격소,해방법생화지표개선현저,유효솔고,재림상상응수선차방법.
Objective To explore the optimal therapy for refractory nephrotic syndrome.Methods 70 patients with refractory nephrotic syndrome were divided into stduygroup and control group.The study group received leflunomide in addition to hormone therapy,while the control group received cyclophosphamide plus hormone.The changes in biochemical indicators and the clinical efficacy were compared between the two groups.Results Levels of cholesterol,triglyceride,and 24h urinary protein were significantly declined and albumin levels were significantly increased in both groups after treatment ( P＜ 0.05 ),The changes in levels of albumin and 24 h urinary protein were more significant in the study group than in the control group ( P＜ 0.05 ).The total effectiveness rate was 82.9％ in the study group and 74.3％ in the control group ( P ＞ 0.05 ).Conclusions Leflunomide combined with glucocorticoids is the optimal therapy for refractory nephrotic syndrome,with a higher effectiveness rate.This method makes biochemical indicators improve significantly and should be the first choice in clinical practice.
