CAJ | 학술논문

目的探讨酒石酸托特罗定(舍尼亭)联合经皮神经电刺激(TENS)治疗老年女性膀胱过度活动症的临床疗效. 方法选取2010年1～6月于我院泌尿外科门诊就诊并确诊为膀胱过度活动症的老年女性患者30例,随机分为两组.单独治疗组应用酒石酸托特罗定治疗,联合治疗组应用酒石酸托特罗定联合TENS治疗,疗程均为10 d.治疗前后应用膀胱过度活动症状评分(OABSS)、患者感知膀胱症状情况分级量表(PPBC)、生活质量评分(QOL)、视觉模拟量表(VAS)及5级疼痛评分法对疗效进行评价. 结果治疗后单独治疗组24 h平均尿急次数、每周尿失禁次数、OABSS评分、PPBC评分、QOL评分、VAS评分及5级疼痛评分分别为(1.67±1.45)次/d、(1.53±1.25)次/周、(6.67±2.55)分、(2.07±0.96)分、(2.07±1.03)分、(3.67±0.90)分、(4.07±0.80)分,较治疗前的(6.40±1.45)次/d、(3.93±1.03)次/周、(13.00±1.00)分、(4.20±0.68)分、(3.80±0.68)分、(7.13±1.19)分、(9.40±1.55)分有明显改善(t=8.94、5.74、8.94、7.03、5.44、9.01、11.85,均P＜0.01)；联合治疗组治疗后分别为(1.27±0.80)次/d、(1.20±0.77)次/周、(5.33±1.72)分、(1.67±0.62)分、(1.47±0.52)分、(2.93±0.80)分、(3.40±0.99)分,较治疗前的(6.20±1.26)次/ d、(4.00±1.25)次/周、(12.73±1.03)分、(4.07±0.80)分、(4.00±0.65)分、(7.47±0.74)分、(9.67±1.35)分亦有明显改善(t=12.77、7.36、14.29、9.21、11.77、16.09、14.55,均P＜0.01).治疗前后联合治疗组VAS评分及5级疼痛评分的评分差值均高于单独治疗组,差异具有统计学意义(t=4.88、2.75,P＜0.01). 结论酒石酸托特罗定联合TENS治疗老年女性膀胱过度活动症状患者下尿路症状群安全、有效,可减轻疼痛程度并改善生活质量.
목적 탐토주석산탁특라정(사니정)연합경피신경전자격(TENS)치료노년녀성방광과도활동증적림상료효. 방법 선취2010년1～6월우아원비뇨외과문진취진병학진위방광과도활동증적노년녀성환자30례,수궤분위량조.단독치료조응용주석산탁특라정치료,연합치료조응용주석산탁특라정연합TENS치료,료정균위10 d.치료전후응용방광과도활동증상평분(OABSS)、환자감지방광증상정황분급량표(PPBC)、생활질량평분(QOL)、시각모의량표(VAS)급5급동통평분법대료효진행평개. 결과 치료후단독치료조24 h평균뇨급차수、매주뇨실금차수、OABSS평분、PPBC평분、QOL평분、VAS평분급5급동통평분분별위(1.67±1.45)차/d、(1.53±1.25)차/주、(6.67±2.55)분、(2.07±0.96)분、(2.07±1.03)분、(3.67±0.90)분、(4.07±0.80)분,교치료전적(6.40±1.45)차/d、(3.93±1.03)차/주、(13.00±1.00)분、(4.20±0.68)분、(3.80±0.68)분、(7.13±1.19)분、(9.40±1.55)분유명현개선(t=8.94、5.74、8.94、7.03、5.44、9.01、11.85,균P＜0.01)；연합치료조치료후분별위(1.27±0.80)차/d、(1.20±0.77)차/주、(5.33±1.72)분、(1.67±0.62)분、(1.47±0.52)분、(2.93±0.80)분、(3.40±0.99)분,교치료전적(6.20±1.26)차/ d、(4.00±1.25)차/주、(12.73±1.03)분、(4.07±0.80)분、(4.00±0.65)분、(7.47±0.74)분、(9.67±1.35)분역유명현개선(t=12.77、7.36、14.29、9.21、11.77、16.09、14.55,균P＜0.01).치료전후연합치료조VAS평분급5급동통평분적평분차치균고우단독치료조,차이구유통계학의의(t=4.88、2.75,P＜0.01). 결론 주석산탁특라정연합TENS치료노년녀성방광과도활동증상환자하뇨로증상군안전、유효,가감경동통정도병개선생활질량.
Objective To study the clinical efficacy of tolterodine tartrate combined with transcutaneous electrical nerve stimulation(TENS)in the treatment of elderly female patients with overactive bladder(OAB).Methods 30 patients with OAB were randomly divided into single treatment with tolterodine tartrate and combination treatment of tolterodine tartrate and TENS for 10d.The efficacy was evaluated by overactive bladder symptom score(OABSS),patient perception of bladder condition(PPBC),quality of life(QOL),visual analogy scale(VAS)and 5 grade pain scores.Results The post-treatment symptoms of urgent urination and urinary incontinence,OABSS,PPBC,QOL,VAS and 5 grade pain scores in single treatment group[(1.67±1.45)times /d,(1.53±1.25)times /week,(6.67±2.55)scores,(2.07±0.96)scores,(2.07±1.03)scores,(3.67±0.90)scores and(4.07±0.80)scores]were improved as compared with pre-treatment[(6.40±1.45)times /d,(3.93±1.03)times/week,(13.00±1.00)scores,(4.20±0.68)scores,(3.80±0.68)scores,(7.13± 1.19)scores and(9.40± 1.55)](t=8.94,5.74,8.94,7.03,5.44,9.01 and 11.85,all P＜0.01).The above indexes in combination treatment group after treatment[(1.27±0.80)times/d,(1.20±0.77)times/week,(5.33±1.72)scores,(1.67±0.62)scores,(1.47±0.52)scores,(2.93±0.80)scores and(3.40±0.99)scores]were also improved as compared with pretreatment[(6.20±1.26)times/d,(4.00±1.25)times/week,(12.73±1.03)scores,(4.07±0.80)scores,(4.00±0.65)scores,(7.47±0.74)scores and(9.67±1.35)scores](t=12.77,7.36,14.29,9.21,11.77,16.09 and 14.55,all P＜0.01).The VAS and 5 grade pain scores were higher in combination treatment group than in single treatment group(t=4.879 and 2.746,P＜0.01).Conclusions Tolterodine tartrate combined with TENS is safe and effective for the treatment of elderly female patients with OAB,and may alleviate pain and improve quality of life.