CAJ | 학술논문

目的观察盐酸法舒地尔治疗蛛网膜下腔出血的临床疗效和安全性.方法选择2009年3月至2010年12月收治的经头部CT或腰椎穿刺检查确诊为自发性蛛网膜下腔出血患者80例,随机分为两组:治疗组40例,除常规治疗外给予法舒地尔注射液治疗；对照组40例,给予尼莫地平注射液治疗.结果盐酸法舒地尔和尼莫地平治疗蛛网膜下腔出血后脑血管痉挛治疗均有效,治疗组有效率为92.5％,对照组为77.5％,两组比较差异有统计学意义(P＜0.05)；治疗组较对照组头痛和颈项强直时间明显缩短(P＜0.05).结论盐酸法舒地尔是一种新型抗脑血管痉挛药物,此药安全、有效,值得临床推广使用.
목적 관찰염산법서지이치료주망막하강출혈적림상료효화안전성.방법 선택2009년3월지2010년12월수치적경두부CT혹요추천자검사학진위자발성주망막하강출혈환자80례,수궤분위량조:치료조40례,제상규치료외급여법서지이주사액치료；대조조40례,급여니막지평주사액치료.결과 염산법서지이화니막지평치료주망막하강출혈후뇌혈관경련치료균유효,치료조유효솔위92.5％,대조조위77.5％,량조비교차이유통계학의의(P＜0.05)；치료조교대조조두통화경항강직시간명현축단(P＜0.05).결론염산법서지이시일충신형항뇌혈관경련약물,차약안전、유효,치득림상추엄사용.
Objective To observe the clinical efficacy and safety of fasudil in the treatment of subarachnoid hemorrhage.Methods Eighty patients with spontaneous subarachnoid hemorrhage confirmed by cranial CT or lumbar puncture from Mar.2009 to Dec.2010 were randomly divided into two groups,treatment group (40 cases) and control group (40 cases).All the patients in the two groups received conventional therapy.Patients in the treatment group received injection of fasudil,patients in the control group received injection of nimodipine.Results Both fasudil and nimodipine were effective to treat cerebral vasospasm following subarachnoid hemorrhage,the effective rate of treatment group was 92.5％ and was 77.5％ in control group,there was significant difference between the two groups ( P ＜0.05 ).The time of headache and neck stiffness in treatment group was shorter than that in control group ( P ＜ 0.05 ).Conclusions Fasudil is worth application for its efficiency and safety in treating cerebral vasospasm following subarachnoid hemorrhage.