CAJ | 학술논문

目的探讨血清载脂蛋白A5(APOA5)水平与急性冠状动脉综合征(ACS)患者血脂谱及高敏性C反应蛋白(hs-CRP)的关系.方法入选587例受试对象,分为对照组(n=232)、稳定性心绞痛(SA)组(n=127)、不稳定性心绞痛(UA)组(n=116)和急性心肌梗死(AMI)组(n=112).抽血分离血清,分别采用ELISA法和免疫比浊法测定血清APOA5以及hs-CRP,并测定血清甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C).比较各组ApoA5、hs-CRP和血脂的血清浓度差异,分析三者之间的相互关系.结果 UA组[(340.6±63.5)μg/L]和AMI组[(373.2±73.8)μg/L]的ApoA5浓度明显高于对照组[(108.7±23.2)μg/L]和SA组[(78.3±20.2)μg/L](均P<0.05).UA组和AMI组的ApoA5与TG(r=0.63和0.67,P<0.05)和hs-CRP(r=0.57和0.55,P<0.05)呈正相关,而ApoA5与TC、HDL-c和LDL-C无明显相关(P>0.05).结论 ACS患者中血清ApoA5浓度显著升高,与血清TG或hs-CRP浓度显著正相关,提示ApoA5的代谢和生理功能在ACS期间均发生了变化,这可能与炎症反应增强有关.
목적 탐토혈청재지단백A5(APOA5)수평여급성관상동맥종합정(ACS)환자혈지보급고민성C반응단백(hs-CRP)적관계.방법 입선587례수시대상,분위대조조(n=232)、은정성심교통(SA)조(n=127)、불은정성심교통(UA)조(n=116)화급성심기경사(AMI)조(n=112).추혈분리혈청,분별채용ELISA법화면역비탁법측정혈청APOA5이급hs-CRP,병측정혈청감유삼지(TG)、총담고순(TC)、고밀도지단백담고순(HDL-C)화저밀도지단백담고순(LDL-C).비교각조ApoA5、hs-CRP화혈지적혈청농도차이,분석삼자지간적상호관계.결과 UA조[(340.6±63.5)μg/L]화AMI조[(373.2±73.8)μg/L]적ApoA5농도명현고우대조조[(108.7±23.2)μg/L]화SA조[(78.3±20.2)μg/L](균P<0.05).UA조화AMI조적ApoA5여TG(r=0.63화0.67,P<0.05)화hs-CRP(r=0.57화0.55,P<0.05)정정상관,이ApoA5여TC、HDL-c화LDL-C무명현상관(P>0.05).결론 ACS환자중혈청ApoA5농도현저승고,여혈청TG혹hs-CRP농도현저정상관,제시ApoA5적대사화생리공능재ACS기간균발생료변화,저가능여염증반응증강유관.
Objective To explore the relationship between serum apolipoprotein A5 (APOA5) and lipid profile or high sensitive C-reactive protein (hs-CRP) in patients with acute coronary syndrome (ACS). Methods Serum apoA5 and hs-CRP levels were measured by ELISA and immunoturbidimetry in control subjects (n=232), patients with stable angina (SA, n=127), unstable angina (UA, n=116) and acute myocardial infarction (AMI, n=112). Triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDL-C) and low density lipoprotein cholesterol (LDL-C) were also measured. Results Compared with controls [(108.7±23.2 )μg/L] and SA patients [(78.3±20.2 )μg/L], serum ApoA5 level was significantly increased in UA [(340. 6±63.5)μg/L] and AMI patients [(373.2±73.8) μg/L] ( all P<0.05 ). ApoA5 was positively correlated with TG (r=0.63 and 0.67, respectively, all P<0.05) and hs-CRP (r=0.57 and 0. 55, respectively, all P<0.05) in UA and AMI patients but there were no significant correlations between ApoA5 and TC, HDL-C and LDL-C in ACS patients (all P>0.05). Conclusion Increased serum apoA5 level and the positive correlation between ApoA5 and serum TG and hs-CRP in ACS patients might reflect increased inflammation responses in ACS patients.