上海第二医科大学学报(英文版)
上海第二醫科大學學報(英文版)
상해제이의과대학학보(영문판)
JOURNAL OF SHANGHAI SECOND MEDICAL UNIVERSITY
2003年
1期
46-49
,共4页
方宁远%张怡%陆惠华%郑迪辉%邬亦贤%郑道声
方寧遠%張怡%陸惠華%鄭迪輝%鄔亦賢%鄭道聲
방저원%장이%륙혜화%정적휘%오역현%정도성
essential hypertension%angiotensin Ⅱ type 1 receptor%gene polymorphism
Objective To detect the A/C1166 polymorphism of angiotensin Ⅱ type-1 receptor (AT1 R) gene in essential hypertensive elderly.MethodsThe A/C1166 polymorphism of AT1 R gene was assessed by polymerase chain reaction restriction fragment length polymorphism (PCR RFLP) in a case control study of 87 essential hypertensive elders (EH) and 55 normotensive elders (NT).ResultsThe genotype frequencies of AA, AC, CC were 0.805, 0.161, 0.034 in EH group and 0.927, 0.073, 0.000 in NT group respectively. The frequency of C1166 allele was higher in EH group (0.115) than in NT group (0.036)(P＜0.05).ConclusionThe results indicate that A/C1166 polymorphism of AT1 R gene may be associated with essential hypertension in elderly.
