北京大学学报（医学版）
北京大學學報（醫學版）
북경대학학보（의학판）
JOURNAL OF BEIJING MEDICAL UNIVERSITY(HEALTH SCIENCES)
2009年
6期
682-686
,共5页
胃肠道%迟效制剂%藻酸盐%黄素单核苷酸%工艺学%制药
胃腸道%遲效製劑%藻痠鹽%黃素單覈苷痠%工藝學%製藥
위장도%지효제제%조산염%황소단핵감산%공예학%제약
Gastrointestinal tract%Delayed-action preparations%Alginates%Flavin mononucleotide%Technology,pharmaceutical
目的:考察核黄素磷酸钠胃漂浮缓释微球的制备、优化和体外性质.方法:采用离子胶凝-烘干法制备了核黄素磷酸钠海藻酸钙胃漂浮缓释微球.结果:考察了微球的外观、包封率、漂浮性能和体外释放,并运用响应曲而法分析、优化了微球处方.结论:优化后的微球外观圆整,包封率为57.49%,体外漂浮8小时以上,释放符合Fick扩散方程.
目的:攷察覈黃素燐痠鈉胃漂浮緩釋微毬的製備、優化和體外性質.方法:採用離子膠凝-烘榦法製備瞭覈黃素燐痠鈉海藻痠鈣胃漂浮緩釋微毬.結果:攷察瞭微毬的外觀、包封率、漂浮性能和體外釋放,併運用響應麯而法分析、優化瞭微毬處方.結論:優化後的微毬外觀圓整,包封率為57.49%,體外漂浮8小時以上,釋放符閤Fick擴散方程.
목적:고찰핵황소린산납위표부완석미구적제비、우화화체외성질.방법:채용리자효응-홍간법제비료핵황소린산납해조산개위표부완석미구.결과:고찰료미구적외관、포봉솔、표부성능화체외석방,병운용향응곡이법분석、우화료미구처방.결론:우화후적미구외관원정,포봉솔위57.49%,체외표부8소시이상,석방부합Fick확산방정.
Objective:To investigate the preparation, optimization and in vitro properties of riboflavin sodium phosphate floating microspheres. Methods: The floating microspheres composed of riboflavin sodium phosphate and calcium alginate were prepared using ion gelatin-oven drying method. Results: The properties of the microspheres were investigated, including the buoyancy, release, appearance and entrapment efficiency. The formulation was optimized by response surface methodology (RSM). Conclusion: The optimized microspheres were round. The entrapment efficiency was 57.49%. All the microspheres could float on the artificial gastric juice over 8 hours. The release of the drug from the microspheres complied with Fick' s diffusion.
