中华普通外科杂志
中華普通外科雜誌
중화보통외과잡지
CHINESE JOURNAL OF GENERAL SURGERY
2008年
9期
706-709
,共4页
张全保%李玉民%李汛%周文策%石斌%陈昊%袁文臻
張全保%李玉民%李汛%週文策%石斌%陳昊%袁文臻
장전보%리옥민%리신%주문책%석빈%진호%원문진
胃肿瘤%多态性%限制性片段长度%聚腺苷二磷酸核糖聚合酶类%疾病遗传易感性
胃腫瘤%多態性%限製性片段長度%聚腺苷二燐痠覈糖聚閤酶類%疾病遺傳易感性
위종류%다태성%한제성편단장도%취선감이린산핵당취합매류%질병유전역감성
Stomach neoplasms%Polymorphism,restriction fragment length%Poly(ADPribose) polymerases%Genetic predisposition to disease
目的 研究多聚ADP核糖聚合酶1(PARP-1)的Val762Ala(T2444C)在中国西北甘肃地区汉族人群胃癌患者和健康对照者中的基因型分布频率,并探讨其与胃癌发病风险的关系.方法 采用PCR-限制性片段长度多态性方法,对138例胃癌患者和110例健康体检者(排除肿瘤和消化系统疾病)进行病例-对照的基因分型研究.以logistic回归和X2检验计算比值比(OR)及其95%可信区间(CJ).结果 Val762Ala(T2444C)的Ala等位基因的分布频率在胃癌组(11.5%)明显高于对照组(4.5%),OR值为3.012(95% CI:1.054~8.603,P=0.033).结论 PARP-1 Val762Ala(T2444C)遗传变异与胃癌易感性相关,PARP-1762Ala等位基因型(2444CC)是胃癌的一个易感性标志.
目的 研究多聚ADP覈糖聚閤酶1(PARP-1)的Val762Ala(T2444C)在中國西北甘肅地區漢族人群胃癌患者和健康對照者中的基因型分佈頻率,併探討其與胃癌髮病風險的關繫.方法 採用PCR-限製性片段長度多態性方法,對138例胃癌患者和110例健康體檢者(排除腫瘤和消化繫統疾病)進行病例-對照的基因分型研究.以logistic迴歸和X2檢驗計算比值比(OR)及其95%可信區間(CJ).結果 Val762Ala(T2444C)的Ala等位基因的分佈頻率在胃癌組(11.5%)明顯高于對照組(4.5%),OR值為3.012(95% CI:1.054~8.603,P=0.033).結論 PARP-1 Val762Ala(T2444C)遺傳變異與胃癌易感性相關,PARP-1762Ala等位基因型(2444CC)是胃癌的一箇易感性標誌.
목적 연구다취ADP핵당취합매1(PARP-1)적Val762Ala(T2444C)재중국서북감숙지구한족인군위암환자화건강대조자중적기인형분포빈솔,병탐토기여위암발병풍험적관계.방법 채용PCR-한제성편단장도다태성방법,대138례위암환자화110례건강체검자(배제종류화소화계통질병)진행병례-대조적기인분형연구.이logistic회귀화X2검험계산비치비(OR)급기95%가신구간(CJ).결과 Val762Ala(T2444C)적Ala등위기인적분포빈솔재위암조(11.5%)명현고우대조조(4.5%),OR치위3.012(95% CI:1.054~8.603,P=0.033).결론 PARP-1 Val762Ala(T2444C)유전변이여위암역감성상관,PARP-1762Ala등위기인형(2444CC)시위암적일개역감성표지.
Objective To investigate the frequency distribution of Val762Ala(T2444C)polymorphism among Han Chinese population in Gansu province,and to explore its relation to the suseeptibihty to gastric cancer. Methods A hospital-based,case-control study was performed involving 138 patients with gastric cancer and 110 healthy controls by PCR-RFLP method.Logistic regression and Chisquare analyses were used to assess OR and 95% CI. Results PARP-1762Ala allele was overexpressed in gastric cancer cases(11.5%)compared with controls(4.5%)(OR=3.012,95%CI 1.054-8.603,P=0.033).Statistic analysis showed increaged risk for gastric cancer patients with the 762Ala allele.Conclusion PARP-1 Val762Ala(T2444C)is related to the risk of gastric cancer,PARP-1762Ala allele could be used as a susceptibility marker for the development of gastric cancer.