CAJ | 학술논문

目的研究多聚ADP核糖聚合酶1(PARP-1)的Val762Ala(T2444C)在中国西北甘肃地区汉族人群胃癌患者和健康对照者中的基因型分布频率,并探讨其与胃癌发病风险的关系.方法采用PCR-限制性片段长度多态性方法,对138例胃癌患者和110例健康体检者(排除肿瘤和消化系统疾病)进行病例-对照的基因分型研究.以logistic回归和X2检验计算比值比(OR)及其95%可信区间(CJ).结果 Val762Ala(T2444C)的Ala等位基因的分布频率在胃癌组(11.5%)明显高于对照组(4.5%),OR值为3.012(95% CI:1.054～8.603,P=0.033).结论 PARP-1 Val762Ala(T2444C)遗传变异与胃癌易感性相关,PARP-1762Ala等位基因型(2444CC)是胃癌的一个易感性标志.
목적 연구다취ADP핵당취합매1(PARP-1)적Val762Ala(T2444C)재중국서북감숙지구한족인군위암환자화건강대조자중적기인형분포빈솔,병탐토기여위암발병풍험적관계.방법 채용PCR-한제성편단장도다태성방법,대138례위암환자화110례건강체검자(배제종류화소화계통질병)진행병례-대조적기인분형연구.이logistic회귀화X2검험계산비치비(OR)급기95%가신구간(CJ).결과 Val762Ala(T2444C)적Ala등위기인적분포빈솔재위암조(11.5%)명현고우대조조(4.5%),OR치위3.012(95% CI:1.054～8.603,P=0.033).결론 PARP-1 Val762Ala(T2444C)유전변이여위암역감성상관,PARP-1762Ala등위기인형(2444CC)시위암적일개역감성표지.
Objective To investigate the frequency distribution of Val762Ala(T2444C)polymorphism among Han Chinese population in Gansu province,and to explore its relation to the suseeptibihty to gastric cancer. Methods A hospital-based,case-control study was performed involving 138 patients with gastric cancer and 110 healthy controls by PCR-RFLP method.Logistic regression and Chisquare analyses were used to assess OR and 95% CI. Results PARP-1762Ala allele was overexpressed in gastric cancer cases(11.5%)compared with controls(4.5%)(OR=3.012,95%CI 1.054-8.603,P=0.033).Statistic analysis showed increaged risk for gastric cancer patients with the 762Ala allele.Conclusion PARP-1 Val762Ala(T2444C)is related to the risk of gastric cancer,PARP-1762Ala allele could be used as a susceptibility marker for the development of gastric cancer.