中华实验外科杂志
中華實驗外科雜誌
중화실험외과잡지
CHINESE JOURNAL OF EXPERIMENTAL SURGERY
2011年
6期
993-995
,共3页
程剑剑%王盛超%何苡%胡为才%李玉光%马利军
程劍劍%王盛超%何苡%鬍為纔%李玉光%馬利軍
정검검%왕성초%하이%호위재%리옥광%마리군
支气管镜%自荧光%非小细胞肺癌
支氣管鏡%自熒光%非小細胞肺癌
지기관경%자형광%비소세포폐암
Bronchoscope%Autofluorescence%Non-small-cell lung carcinoma
目的 探讨自荧光支气管镜(AFB)在非小细胞肺癌(NSCLC)患者术前评估中的应用价值.方法 将254例患者随机分为白光支气管镜(WLB)检查组和AFB检查组,比较两组手术患者的切缘癌细胞阳性率、切缘不典型增生阳性率,和两组术后患者的复发率及生存率.结果 AFB组NSCLC术后切缘癌细胞阳性率(1.9%)及不典型增生阳性率(3.8%),显著低于WLB组(5.7%、23.8%)(x2=21.755,P＜0.05),AFB组术后局部复发率(10.4%)显著低于WLB组(38.5%)(x2=23.692,P＜0.05),1、2、3年生存率AFB组分别为91.5%、78.3%、63.2%显著高于WLB组69.7%、48.4%、33.6%(x2=16.815、14.167、13.413,P＜0.05).结论 AFB有助于识别NSCLC并确定其边界,为手术治疗提供可靠依据,降低术后患者局部复发率,提高患者生存率,在NSCLC患者术前评估中有重要意义.
目的 探討自熒光支氣管鏡(AFB)在非小細胞肺癌(NSCLC)患者術前評估中的應用價值.方法 將254例患者隨機分為白光支氣管鏡(WLB)檢查組和AFB檢查組,比較兩組手術患者的切緣癌細胞暘性率、切緣不典型增生暘性率,和兩組術後患者的複髮率及生存率.結果 AFB組NSCLC術後切緣癌細胞暘性率(1.9%)及不典型增生暘性率(3.8%),顯著低于WLB組(5.7%、23.8%)(x2=21.755,P＜0.05),AFB組術後跼部複髮率(10.4%)顯著低于WLB組(38.5%)(x2=23.692,P＜0.05),1、2、3年生存率AFB組分彆為91.5%、78.3%、63.2%顯著高于WLB組69.7%、48.4%、33.6%(x2=16.815、14.167、13.413,P＜0.05).結論 AFB有助于識彆NSCLC併確定其邊界,為手術治療提供可靠依據,降低術後患者跼部複髮率,提高患者生存率,在NSCLC患者術前評估中有重要意義.
목적 탐토자형광지기관경(AFB)재비소세포폐암(NSCLC)환자술전평고중적응용개치.방법 장254례환자수궤분위백광지기관경(WLB)검사조화AFB검사조,비교량조수술환자적절연암세포양성솔、절연불전형증생양성솔,화량조술후환자적복발솔급생존솔.결과 AFB조NSCLC술후절연암세포양성솔(1.9%)급불전형증생양성솔(3.8%),현저저우WLB조(5.7%、23.8%)(x2=21.755,P＜0.05),AFB조술후국부복발솔(10.4%)현저저우WLB조(38.5%)(x2=23.692,P＜0.05),1、2、3년생존솔AFB조분별위91.5%、78.3%、63.2%현저고우WLB조69.7%、48.4%、33.6%(x2=16.815、14.167、13.413,P＜0.05).결론 AFB유조우식별NSCLC병학정기변계,위수술치료제공가고의거,강저술후환자국부복발솔,제고환자생존솔,재NSCLC환자술전평고중유중요의의.
Objective To evaluate the applied value of autofluorescence bronchoscopy (AFB) during the process of the preoperative evaluation of non-small cell lung cancer. Methods 254 patients were classified randomly into white light bronchoscopy ( WLB ) inspection group and AFB inspection group.The positive incisal edge rate of the cancer cells, the positive incisal edge rate of atypical hyperplasia, local recurrence rate and survival rate were compared. Results The positive incisal edge rate ( 1. 9% ) and atypical hyperplasia rate (3. 8% ) in AFB inspection group were significantly lower than in WLB group (5.7% , 23.8% ,x2 =21.755, P ＜0. 05). The local recurrence rate in AFB inspection group (10.4%) was significantly lower than WLB group (38. 5% ,x 2= 23. 692, P ＜ 0. 05). One-, 2- and 3-year survival rate in AFB group (91. 5% , 78. 3% , and 63. 2% ) was significantly higher than in WLB group (69. 7% ,48.4% , 33. 6% ,x2 = 16. 815, 14. 167, 13. 413, P ＜ 0. 05). Conclusion AFB is important during the process of preoperative evaluation of non-small cell lung cancer. It can find the frequent bronchus submucosa transferring of lung cancer and ensure its edge. It can provide the reliable basis for the surgical operation, reduce the local recurrence rate and increase the survival rate.
