中华肾脏病杂志
中華腎髒病雜誌
중화신장병잡지
2011年
7期
504-510
,共7页
周弋%孙乔%阮晓楠%徐望红%赵根明%顾建钧%杨黎明%傅筱瑾%白云%张鸿%邱桦
週弋%孫喬%阮曉楠%徐望紅%趙根明%顧建鈞%楊黎明%傅篠瑾%白雲%張鴻%邱樺
주익%손교%원효남%서망홍%조근명%고건균%양려명%부소근%백운%장홍%구화
肾疾病%患病率%横断面研究
腎疾病%患病率%橫斷麵研究
신질병%환병솔%횡단면연구
Kidney disease%Prevalence%Cross-sectional study
目的 了解上海市浦东新区社区居民慢性肾脏病(CKD)的患病率及主要危险因素.方法 2008年4月至7月,在上海市浦东新区随机多阶段抽取20～80岁的社区居民5584人进行问卷调查,进行横断面研究.收集一般情况和生活方式等信息.收集空腹血和晨尿,榆测Scr、尿肌酐(Ucr)及尿微量白蛋白等指标,计算尿白蛋白和肌酐比值(ACR),并依Scr水平计算肾小球滤过率(eGFR).结果 上海浦东新区成年居民白蛋白尿、肾功能下降和CKD的标化患病率分别为9.9%(男性8.0%、女性12.4%)、1.1%(男性1.3%、女性0.9%)和1 1.0%(男性8.8%,女性12.7%).女性CKD患病率高于男性,并随年龄增长而上升.调整年龄和性别后,城郊患病率问差异无统计学意义.多因素Logistic回归分析显示,高龄、女性、高血压、高空腹血糖、高三酰甘油血症、超重或肥胖是白蛋白尿、CKD的独立危险因素.结论 上海市浦东新区成人CKD的患病率接近甚至高于国内外既往研究结果.肾脏损伤已成为危及该地区居民健康的重大公共卫生问题,需重视CKD的早期发现和干预,避免终末期肾脏病(ESRD)和相关并发症的发生.
目的 瞭解上海市浦東新區社區居民慢性腎髒病(CKD)的患病率及主要危險因素.方法 2008年4月至7月,在上海市浦東新區隨機多階段抽取20～80歲的社區居民5584人進行問捲調查,進行橫斷麵研究.收集一般情況和生活方式等信息.收集空腹血和晨尿,榆測Scr、尿肌酐(Ucr)及尿微量白蛋白等指標,計算尿白蛋白和肌酐比值(ACR),併依Scr水平計算腎小毬濾過率(eGFR).結果 上海浦東新區成年居民白蛋白尿、腎功能下降和CKD的標化患病率分彆為9.9%(男性8.0%、女性12.4%)、1.1%(男性1.3%、女性0.9%)和1 1.0%(男性8.8%,女性12.7%).女性CKD患病率高于男性,併隨年齡增長而上升.調整年齡和性彆後,城郊患病率問差異無統計學意義.多因素Logistic迴歸分析顯示,高齡、女性、高血壓、高空腹血糖、高三酰甘油血癥、超重或肥胖是白蛋白尿、CKD的獨立危險因素.結論 上海市浦東新區成人CKD的患病率接近甚至高于國內外既往研究結果.腎髒損傷已成為危及該地區居民健康的重大公共衛生問題,需重視CKD的早期髮現和榦預,避免終末期腎髒病(ESRD)和相關併髮癥的髮生.
목적 료해상해시포동신구사구거민만성신장병(CKD)적환병솔급주요위험인소.방법 2008년4월지7월,재상해시포동신구수궤다계단추취20～80세적사구거민5584인진행문권조사,진행횡단면연구.수집일반정황화생활방식등신식.수집공복혈화신뇨,유측Scr、뇨기항(Ucr)급뇨미량백단백등지표,계산뇨백단백화기항비치(ACR),병의Scr수평계산신소구려과솔(eGFR).결과 상해포동신구성년거민백단백뇨、신공능하강화CKD적표화환병솔분별위9.9%(남성8.0%、녀성12.4%)、1.1%(남성1.3%、녀성0.9%)화1 1.0%(남성8.8%,녀성12.7%).녀성CKD환병솔고우남성,병수년령증장이상승.조정년령화성별후,성교환병솔문차이무통계학의의.다인소Logistic회귀분석현시,고령、녀성、고혈압、고공복혈당、고삼선감유혈증、초중혹비반시백단백뇨、CKD적독립위험인소.결론 상해시포동신구성인CKD적환병솔접근심지고우국내외기왕연구결과.신장손상이성위위급해지구거민건강적중대공공위생문제,수중시CKD적조기발현화간예,피면종말기신장병(ESRD)화상관병발증적발생.
Objective To investigate the prevalence and risk factors of chronic kidney disease (CKD) in adult residents of Shanghai Pudong New Area. Methods A total of 5584 residents aged 20-80 years old were randomly selected from Shanghai Pudong New Area through multistage sampling and interview between April and July 2008. Fasting blood samples and morning urine samples were collected to detect Scr and urinary albumin and creatinine. Urine albumin to creatinine ratio (ACR) and glomerular filtration rate (GFR) was calculated to estimate the renal function. Logistic regression model was used to examine the associations of demographic and lifestyle factors with indicators of kidney damage. Results The age-standardized prevalence of albuminuria, reduced renal function and CKD was 9.9% (male 8.0%, female 12.4%), 1.1% (male 1.3%, female 0.9%) and 11.0%(male 8.8%, female 12.7%), respectively. The prevalence of CKD was higher in female and increased with age. No significant difference in the prevalence was observed between urban and rural areas. Elder, female, high blood pressure, high fasting glucose, dyslipidemia and obesity were associated with CKD independently. Conclusions The prevalence of CKD in Shanghai Pudong New Area is comparable to that previously reported in China or other developed countries, and even higher. CKD is going to be a public health problem and warrants the community-integrated control strategy to prevent the incidence of end-stage renal disease (ESRD) and related complications.
