CAJ | 학술논문

目的:探讨前列腺增生(benign prostatic hyperplasia,BPH)造成患者膀胱出口梗阻(blader outlet obstruction,BOO)后膀胱逼尿肌中转化生长因子β(transforming growth factor-β,TGF-β)的表达变化.方法:BPH患者54例,分为逼尿肌稳定组(33例)和逼尿肌过度活动(detrusor overactivity,DO)组(21例).对照组15例为同期在我院因膀胱癌施行开放手术的男性患者,应用免疫组化观察各组逼尿肌中TGF-β的表达.结果:BPH患者包括逼尿肌稳定组与DO组TGF-β的表达水平均明显高于对照组,在对照组、逼尿肌稳定组、DO组之间两两比较差异均有统计学意义(P＜0.01).结论:BPH造成BOO后逼尿肌中TGF-β的表达明显增高,这种变化可能与BOO后膀胱逼尿肌纤维化及DO相关.
목적:탐토전렬선증생(benign prostatic hyperplasia,BPH)조성환자방광출구경조(blader outlet obstruction,BOO)후방광핍뇨기중전화생장인자β(transforming growth factor-β,TGF-β)적표체변화.방법:BPH환자54례,분위핍뇨기은정조(33례)화핍뇨기과도활동(detrusor overactivity,DO)조(21례).대조조15례위동기재아원인방광암시행개방수술적남성환자,응용면역조화관찰각조핍뇨기중TGF-β적표체.결과:BPH환자포괄핍뇨기은정조여DO조TGF-β적표체수평균명현고우대조조,재대조조、핍뇨기은정조、DO조지간량량비교차이균유통계학의의(P＜0.01).결론:BPH조성BOO후핍뇨기중TGF-β적표체명현증고,저충변화가능여BOO후방광핍뇨기섬유화급DO상관.