中国医药导报
中國醫藥導報
중국의약도보
CHINA MEDICAL HERALD
2009年
24期
10-12
,共3页
固体脂质纳米粒%载体%口服给药%经皮给药
固體脂質納米粒%載體%口服給藥%經皮給藥
고체지질납미립%재체%구복급약%경피급약
Solid lipid nanoparticles%Cartier%Oral administration%Transdermal administration
固体脂质纳米粒是近年来很受重视的一种新型药物传递载体,它综合了传统胶体给药系统如乳剂、脂质体及聚合物纳米粒等的优点,具有靶向、控释、提高药物稳定性、毒性小、可大批量生产等特性,可供多途径给药.本文就近年来固体脂质纳米粒的组成、制备方法、在给药途径中的应用以及发展前景作一综述.
固體脂質納米粒是近年來很受重視的一種新型藥物傳遞載體,它綜閤瞭傳統膠體給藥繫統如乳劑、脂質體及聚閤物納米粒等的優點,具有靶嚮、控釋、提高藥物穩定性、毒性小、可大批量生產等特性,可供多途徑給藥.本文就近年來固體脂質納米粒的組成、製備方法、在給藥途徑中的應用以及髮展前景作一綜述.
고체지질납미립시근년래흔수중시적일충신형약물전체재체,타종합료전통효체급약계통여유제、지질체급취합물납미립등적우점,구유파향、공석、제고약물은정성、독성소、가대비량생산등특성,가공다도경급약.본문취근년래고체지질납미립적조성、제비방법、재급약도경중적응용이급발전전경작일종술.
In recent years,the SLNs have been reposed as potential drug cartier systems.They offer the possibility of controlled drug release and drug targeting and produce protection of incorporated active compounds against degradation,which combine the advantages of other traditional collodial systems(i-e.microemulsions,liposomes and polymeric nanoparticles).SLNs formulations for various application routes(orat,parenterat,dermal,pulmonary,ocular)have been developed and thoroughly characterized in vitro and in vivo.This paper is focused on general ingredients,the preparation,application routes and development prospect.
